Sports Medical Sciences

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Summary of Activity

Our goal is to provide evidence-based information to solve the current social problems; global warming and advanced aging. Human beings have lived broadly on the earth by their high ability to adapt the hot/ cold environments by nature. However, the amenity that they acquired, including food and medical conditions, has deteriorated their ability and the waste of natural resources to attain the amenity has accelerated the depletion of the resources to cause the global warming. To cut the viscous circle, we would like to propose to reactivate their genetic resources to adapt the environments.

Research Subject

• ? To provide the strategy to prevent heat illness during exercise
• ? To provide the strategy to prevent lifestyle-related diseases with deterioration of physical fitness with aging
• ? To provide the epigenetic mechanisms for the effects of exercise training

Outlook for Research

We have developed e-Health Promotion System, composed of Interval Walking Training (IWT), portable calorimeter, and IT network system. By using the system, we have accumulated the database (DB) on the effects of 5-mo IWT in several thousand middle-aged and older people. By using the DB, we will develop a program to predict the effects of IWT to encourage the participants to continue IWT from their physical characteristics with genetic background. Thereby, we will transform medical service from treatment to prevention.

Major Publications

1. Masuki S, Sumiyoshi E, Koshimizu T, Qian J, Higuchi K, Tsujimoto G, and Nose H. Voluntary locomotion linked with cerebral activation is mediated by vasopressin V1a receptors in free-moving mice. J Physiol (Lond.) in press. Doi:10.1113/jphysiol.2013.251876

2. Kamijo Y, Ikegawa S, Okada Y, Masuki S, Okazaki K, Uchida K, Sakurai M, and Nose H. Enhanced renal Na+ reabsorption by carbohydrate in beverages during restitution from thermal and exercise-induced dehydration in men, Am J Physiol 303: R824-R833, 2012. DOI: 10.1152.ajpregu.00588.2011.

3. Kamijo Y, Okada Y, Ikegawa S, Okazaki K, Goto M, and Nose H. Skin sympathetic nerve activity component synchronizing with cardiac cycle is involved in hypovolemic suppression of cutaneous vasodilatation in hyperthermia. J Physiol Lond) 589: 6231-6242, 2011.

4. Morikawa M, Okazaki K, Masuki S, Kamijo Y, Yamazaki T, Gen-no H, and Nose H. Physical fitness and indices of . lifestyle-related diseases before and after interval walking training in middle-aged and older males and females. Br J Sports Med 45: 216-224, 2011.

5. Ikegawa S, Kamijo Y, Okazaki K, Masuki S, Okada Y, and Nose H. Effects of hypohydration on thermoregulation during exercise before and after 5-day aerobic training in a warm environment in young men. J Appl Physiol 110: 972-980, 2011.

6. Miyagawa K, Kamijo Y, Ikegawa S, Goto M, and Nose H. Reduced hyperthermia-induced cutaneous vasodilation and enhanced exercise-induced plasma water loss at simulated high altitude (3,200m) in humans. J Appl Physiol 110: 157-165, 2011.

7. Masuki S, Mori M, Tabara Y, Miki T, Morikawa M, Miyagawa K, Higuchi K, and Nose H for the Shinshu University Genetic Research Consortium. Vasopressin V1a receptor polymorphism and high-intensity interval walking training effects in middle-aged and older people. Hypertension 55: 747-754, 2010.

8. Goto M, Okazaki K, Kamijo Y, Ikegawa S, Masuki S, Miyagawa K, and Nose H. Protein and carbohydrate supplementation during 5-day aerobic training enhanced plasma volume expansion and thermoregulatory adaptation in young men. J Appl Physiol 109: 1247-1255, 2010.

9. Okazaki K, Ichinose T, Mitono H, Chen M, Masuki S, Endoh H, Hayase H, Tatsuya Doi T, and Nose H. Impact of protein and carbohydrate supplementation on plasma volume expansion and thermoregulatory adaptation by aerobic training in older men. J Appl Physiol 107: 725-733, 2009.

10. Masuki S and Nose H. Increased cerebral activity suppresses baroreflex control of heart rate in freely moving mice. J Physiol (Lond) 587: 5783-5794, 2009.