Surgery(Gastroenterological, Transplantation, Pediatrics)

Staff List

Summary of Activity

In the first department of surgery, we conduct clinical practice and research into three groups of hepatobiliary pancreatic group, digestive tract group, transplant and pediatric surgery group.
The main target of treatment are gastroenterological malignancies such as liver cancer, pancreas cancer, biliary tract cancer, esophageal cancer, gastric cancer and colorectal cancer. In addition to surgical treatment, comprehensive treatment such as diagnosis and chemotherapy is the corresponding area.
In transplantation and pediatric group, living donor liver transplantation and cadaveric donor liver transplantation for end-stage liver disease and some liver-related metabolic disease have been carried out with low mortality rate.
Clinical research and basic research on digestive tract cancer, transplantation, regenerative medicine are also conducted. Please see the pages of each groups for details of research contents.

Clinical Subject
? Improvement of operative results in hepato-biliary pancreqatic malignancy.
? Combination therapy of extended surgical operation and anti-cancer drugs against advanced colorectal and gastric cancer.
? Less invasive thoracoscopic/laparoscopic surgery for esophageal cancer, gastric cancer, colorectal cancer, hepatocellular carcinoma, pancreatic tumor and other GI malignancies.
? Living donar liver transplantation and caderveric donor liver transplantation for chronic liver disease, acute liver failure and metabolic disorder.
? Surgical treatment for various pediatric disease.

Divisions:
1. Hepato-biliary pancreatic surgery group
2. Digestive tract surgery group
3. Transplantation and pediatric surgery group

Major Publications

Division of Gastrointestinal Surgery

Koide N, Nishio A, Sato T, Sugiyama A, Miyagawa S. Significance of macrophage chemoattractant protein-1 expression and macrophage infiltration in squamous cell carcinoma of the esophagus. Am J Gastroenterol 2004; 99: 1667-74.

Saito H, Yamaoka Y, Ishizone S, Maruta F, Sugiyama A, Graham DY, Yamauchi K, Ota H, Miyagawa S. Roles of virD4 and cagG genes in the cag pathogenicity island of Helicobacter pylori using a Mongolian gerbil model. Gut 2005; 54: 584-90.

Ishizone S, Yamauchi K, Kawa S, Suzuki T, Shimizu F, Harada O, Sugiyama A, Miyagawa S, Fukuda M, Nakayama J. Clinical utility of quantitative RT-PCR targeted to alpha1,4-N-acetylglucosaminyltransferase mRNA for detection of pancreatic cancer. Cancer Sci 2006; 97: 119-26.

Ishizone S, Maruta F, Saito H, Koide N, Sugiyama A, Nakayama J, Miyagawa S. Efficacy of S-1 for patients with peritoneal metastasis of gastric cancer. Chemotherapy 2006; 52: 301-7.

Akita N, Maruta F, Seymour LW, Kerr DJ, Parker AL, Asai T, Oku N, Nakayama J, Miyagawa S: Identification of oligopeptides binding to peritoneal tumors of gastric cancer. Cancer Sci 2006; 97: 1075-81.

Suzuki K, Hayama M, Nakamura M, Yamauchi K, Maruta F, Miyagawa S, Ota H: Trefoil factor 2 in gland mucous cell mucin in the mucous gel covering normal or damaged gastric mucosa using the Mongolian gerbil model. Scand J Gastroenterol 2006; 41: 1390-7.

Koide N, Saito H, Suzuki A, Sato T, Koiwai K, Nakamura N, Miyagawa S.Clinicopathologic features and histochemical analyses of proliferative activity and angiogenesis in small cell carcinoma of the esophagus.J Gastroenterol 2007; 42: 932-8.

Yanagisawa Y, Maruta F, Iinuma N, Ishizone S, Koide N, Nakayama J, Miyagawa S. Modified Irinotecan/5FU/Leucovorin therapy in advanced colorectal cancer and predicting therapeutic efficacy by expression of tumor-related enzymes.Scand J Gastroenterol 2007; 42: 477-84.Komatsu D, Kato M, Nakayama J, Miyagawa S, Kamata T.Oncogene. NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression. 2008 ;27:4724-32.

Komatsu D, Koide N, Hiraga R, Furuya N, Akamatsu T, Uehara T, Miyagawa S Gastric schwannoma exhibiting increased fluorodeoxyglucose uptake..Gastric Cancer. 2009;12:225-8.

Division of Liver transplantation
Ikegami T, Masuda Y, Ohno Y, Mita A, Kobayashi A, Urata K, Nakazawa Y, Miwa S, Hashikura Y, Miyagawa S.Prognosis of adult patients transplanted with liver grafts < 35% of their standard liver volume. Liver Transpl. 2009 ;15:1622-30.

Ikegami T, Masuda Y, Ohno Y, Urata K, Nakazawa Y, Miwa S, Hashikura Y, Miyagawa S.Arterial reconstruction in a case of subintimal dissection of celiac arterial tributaries in living donor liver transplantation: Transplant Proc. 2008 ;40:3794-6.

Ikegami T, Hashikura Y, Nakazawa Y, Urata K, Mita A, Ohno Y, Terada M, Miyagawa S, Kushima H, Kondoh S. Risk factors contributing to hepatic artery thrombosis following living-donor liver transplantation. J Hepatobiliary Pancreat Surg. 2006;13(2):105-9.

Hashikura Y, Ikegami T, Nakazawa Y, Urata K, Mihara M, Mita A, Sakon M, Miyagawa S, Ikeda S. Domino liver transplantation in living donors. Transplant Proc. 2005

Mar;37(2):1076-8

.Mita A, Hashikura Y, Tagawa Y, Nakayama J, Kawakubo M, Miyagawa S. Expression of Fas ligand by hepatic macrophages in patients with fulminant hepatic failure. Am J Gastroenterol. 2005 Nov;100(11):2551-9.

Ogawa S, Tagawa Y, Kamiyoshi A, Suzuki A, Nakayama J, Hashikura Y, Miyagawa S. Crucial roles of mesodermal cell lineages in a murine embryonic stem cell-derived in vitro liver organogenesis system. Stem Cells. 2005 ;23(7):903-13.

Suzuki F, Hashikura Y, Ise H, Ishida A, Nakayama J, Takahashi M, Miyagawa S, Ikeda U. MCI-186 (edaravone), a free radical scavenger, attenuates hepatic warm ischemia-reperfusion injury in rats. Transpl Int. 2005 Jul;18(7):844-53.

Yazaki M, Hashikura Y, Takei Y, Ikegami T, Miyagawa S, Yamamoto K, Tokuda T, Kobayashi K, Saheki T, Ikeda S. Feasibility of auxiliary partial orthotopic liver transplantation from living donors for patients with adult-onset type II citrullinemia. Liver Transpl. 2004 Apr;10(4):550-4.

Hashikura Y, Ikegami T, Nakazawa Y, Urata K, Ogino S, Terada M, Miyagawa S, Kawasaki S, Takei Y, Ikeda S. Delayed domino liver transplantation: use of the remnant liver of a recipient of a temporary auxiliary orthotopic liver transplant as a liver graft for another patient. Transplantation. 2004 Jan 27;77(2):324.

Nakazawa Y, Chisuwa H, Mita A, Ikegami T, Hashikura Y, Terada M, Nakayama J, Kawasaki S. Life-threatening veno-occlusive disease after living-related liver transplantation. Transplantation. 2003 Mar 15;75(5):727-30.

Division of Hepato-Biliary-Pancreatic Surgery
Kobayashi A, Miwa S, Nakata T, Miyagawa S Disease recurrence patterns after R0 resection of hilar cholangiocarcinoma.Br J Surg. 2010 ;97:56-64.

Nakata T, Kobayashi A, Miwa S, Soeda J, Uehara T, Miyagawa S.Clinical and pathological features of primary carcinoma of the cystic duct.J Hepatobiliary Pancreat Surg. 2009;16:75-82.
 
Kobayashi A, Miyagawa S, Miwa S, Nakata T.Prognostic impact of anatomical resection on early and late intrahepatic recurrence in patients with hepatocellular carcinoma.J Hepatobiliary Pancreat Surg. 2008;15:515-21.

Miwa S, Kobayashi A, Akahane Y, Nakata T, Mihara M, Kusama K, Ogawa S, Soeda J, Miyagawa S. Is major hepatectomy with pancreatoduodenectomy justified for advanced biliary malignancy? J Hepatobiliary Pancreat Surg. 2007;14(2):136-41.

Shimizu A, Maruta F, Akita N, Miwa S, Seymour LW, Kerr DJ, Parker AL, Miyagawa S. Identification of an oligopeptide binding to hepatocellular carcinoma. Oncology. 2006;71(1-2):136-45.

Nakata T, Kobayashi A, Miwa S, Soeda J, Miyagawa S. Impact of tumor spread to the cystic duct on the prognosis of patients with gallbladder carcinoma. World J Surg. 2007 Jan;31(1):155-61; discussion 162-3.

Kobayashi A, Kawasaki S, Miyagawa S, Miwa S, Noike T, Takagi S, Iijima S, Miyagawa Y. Results of 404 hepatic resections including 80 repeat hepatectomies for hepatocellular carcinoma. Hepatogastroenterology. 2006 Sep-Oct;53(71):736-41.

Miwa S, Miyagawa S, Kobayashi A, Akahane Y, Nakata T, Mihara M, Kusama K, Soeda J, Ogawa S. Predictive factors for intrahepatic cholangiocarcinoma recurrence in the liver following surgery. J Gastroenterol. 2006 Sep;41(9):893-900. 

Misawa R, Ise H, Takahashi M, Morimoto H, Kobayashi E, Miyagawa S, Ikeda U. Development of liver regenerative therapy using glycoside-modified bone marrow cells. Biochem Biophys Res Commun. 2006 Apr 7;342(2):434-40. Epub 2006 Feb 9. 

Ichikawa E, Hida S, Omatsu Y, Shimoyama S, Takahara K, Miyagawa S, Inaba K, Taki S. Defective development of splenic and epidermal CD4+ dendritic cells in mice deficient for IFN regulatory factor-2. Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3909-14.