Emergency and Critical Care Medicine

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Summary of Activity

Our emergency and critical care center treats diverse diseases in critically ill patients with acute illness, including out-of-hospital cardiac arrest, cardiovascular diseases, shock, sepsis, trauma, or burn. We, emergency and critical care physicians are trained to judge their patient's severity and urgency grades immediately after emergency room arrival, in ambulance car and helicopter, or on-site. Furthermore, we are also specialized in advanced life support and life-saving technique of critical care.

Research Subject

• ? Improvement in outcomes of out-of-hospital cardiac arrest or cardiogenic shock
• ? Control of multidrug-resistant bacterium in intensive care unit
• ? Assessment of the effect of renal replacement therapy on patients with sepsis

Outlook for Research

We facility to promote clinical and translational research strategically in our emergency and critical care center and emergency centers in Nagano Prefecture. We carry out high-quality clinical research on out-of-hospital cardiac arrest, cardiogenic shock, acute myocardial infarction, or renal replacement therapy for sepsis.

Major Publications

1. Okamoto K, Hamaguchi M, Kukita I, Kikuta K, Sato T: Efficacy of inhaled nitric oxide in children with acute respiratory distress syndrome. Chest 114(3):827-833, 1998

2. Moriyama S, Okamoto K, Tabira Y, Kikuta K, Kukita I, Hamaguchi M, Kitamura N: Evaluation of oxygen consumption and resting energy expen-diture in critically ill patients with systemic inflammatory responsesyndrome. Crit Care Med 27(10):2133-2136, 1999

3. Okamoto K, Kukita I, Hamaguchi M, Motoyama T, Muranaka H, Harada T: Combined effects of inhaled nitric oxide and positive end-expiratory pressure during mechanical ventilation in acute respiratory distress syndrome. Artificial Organs 24(5):390-395, 2000

4. Okamoto K, Kukita I, Hamaguchi M, Kikuta K, Matsuda K, Motoyama T: Combination of inhaled nitric oxide therapy and inverse ratio ventilation in patients with sepsis-associated acute respiratory distress syndrome. Artificial Organs 24(11):902-908, 2000.

5. Namihira T. Katsuki S, Hackam R, Akiyama H, Okamoto K: Production of nitric oxide using a pulsed arc discharge. IEEE Transactions on Plasma Science 30(5):1993-1998, 2002

6. Motoyama T, Okamoto K, Kukita I, Hamaguchi M, Kinoshita Y, Ogawa H: Possible role of increased oxidant stress in multiple organ failure after systemic inflammatory response syndrome.  Crit Care Med 31(4):1048-1052, 2003

7. Adachi N, Hirota M, Hamaguchi M, Okamoto K, Watanabe K, Naraki T, Endo F: Serum cytochrome c level as a prognostic indicator in patients with systemic inflammatory response syndrome.  Clinica Chimica Acta 342:127-136, 2004

8. Iwashita T, Koyama J, Dohgomori D, Okudera H, Hongo K, Okamoto K: Comparison of a laryngoscope and newly designed airway device for tracheal intubation: an experimental study.  Medical Postgraduates 45(2):202-208, 2007

9. Dohgomori H, Shibata M, Okamoto K: Application of normal Saline to ultrasonography as an alternative to gel for internal jugular venous cannulation.  Can J Anesth 54(3):246, 2007

10. Kikuchi1 T, Toba S, Sekiguchi1 S, Iwashita T, Imamura H, Kitamura M, Nitta K, Mochizuki K, Okamoto K：Protocol-based noninvasive positive pressure ventilation for acute respiratory failure. In submitting, 2010