Pathology

Staff List

Summary of Activity

Pathology, an unfamiliar research field, clarifies the disease process to death. Pathologists observe the tissue specimens sampled from the lesion of patients, give the diagnosis and further make final diagnosis after autopsy examination. They contribute to the advanced medicine through conferences with clinicians. Pathology, research of etiopathogenesis of diseases, makes the bases of pathologic diagnosis. In our department, we can devote in advanced biomedical research with the pride of physician engaged in patient care.

Research Subject

• ?Collagen disease, vasculitis, glomerulonephritis:
  Contribution of innate immunity activated by various microorganisms
• ?Epstein-Barr virus-related diseases:
  Diseases caused by ubiquitous virus in human beings in specific conditions

Outlook for Research

• ? Prevention and treatment of intractable diseases caused via immune mechanisms
• ? Lower frequency of complications caused with immune suppression in patients receiving advanced medical care

Major Publications

1. Kobayashi M, Matsumoto Y, Ohya M, Harada K, Kanno H: Histological and immunohistochemical evaluation of infiltrating inflammatory cells in Kawasaki disease arteritis lesions. Appl. Immunohistochem. Mol. Morphol. 29(1): 62-67, 2021

2. Kobayashi M, Matsumoto Y, Satomi H, Tateishi A, Ohya M, Ito I, Kanno H: The ratio of CD163-positive macrophages to Iba 1-positive macrophages is low in the intima in the early stage of cutaneous arteritis. Immunol. Res. 68(3): 152-160, 2020

3. Yamamoto Y, Tsuzuki T, Akatsuka J, Ueki M, Morikawa H, Numata Y, Takahara T, Tsuyuki T, Tsutsumi K, Nakazawa R, Shimizu A, Maeda I, Tsuchiya S, Kanno H, Kondo Y, Fukumoto M, Tamiya G, Ueda N, Kimura G: Automated acquisition of explainable knowledge from unannotated histopathology images. Nat. Commun. 10(1): 5642, 2019

4. Ohya M, Nakazawa K, Kanno H: Lower number of 5-hydroxymethylcytosine-expressing cells in plasma cell myeloma than in reactive plasma cell hyperplasia: a useful immunohistochemical approach for identification of neoplastic plasma cells. Pathology 51(1): 81-85, 2019

5. Ichimata S, Kobayashi M, Shimojo H, Katoh N, Yazaki M, Kanno H: Usefulness of gastroduodenal biopsy in the differential diagnosis of systemic AH amyloidosis from systemic AL amyloidosis. Histopathology 73(2): 230-239, 2018

6. Tateishi A, Ohira S, Yamamoto Y, Kanno H: Histopathological findings of pregnancy induced hypertension: histopathology of early-onset type reflects two stage disorder theory. Virchows Arch. 472(4): 635-642, 2018

7. Kobayashi M, Ogawa E, Okuyama R, Kanno H: In vasculitis of small muscular arteries, activation of vessel-infiltrating CD8 T cells seems to be antigen-independent. Virchows Arch. 472(2): 271-279, 2018