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Microbiology and Immunology
| Master's Program | Human Sciences, Graduate School of Medicine |
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| Doctor's Program | Medical Science Division, Department of Medical Science, Graduate School of Medicine, Science and Technology |
| Senior Assistant Professor | KOJIMA Katsuhiko |
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E-mail ： immunol(at)shinshu-u.ac.jp
※ Change (at) to @ when you send an e-mail.
Today, number of patient with Kawasaki disease reached 10,000 per a year in Japan. In many cases, the patients acquire their health after the treatment, but some children develop coronary artery aneurysms. Evidences in the study of Kawasaki disease suggest genetic factors might be involved in Kawasaki disease. So we investigate genetic background of the patients in order to contribute to the treatment and the diagnosis.
We believe our research contributes to human health.
1. Yamada K., Tsukahara T., Yoshino K., Kojima K., Agawa H., Yamashita Y., Amano Y., Hatta M., Matsuzaki Y., Kurotori N., Wakui K., Fukushima Y., Osada R., Shiozawa T., Sakashita K., Koike K., Kumaki S., Tanaka N. and Takeshita T.: Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2 locus. Retrovirology, 6, 79, 2009.
2. Yamashita Y., Kojima K., Tsukahara T., Agawa H., Yamada K., Amano Y., Kurotori N., Tanaka N., Sugamura K., Takeshita T.: Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor β chain. J Cell Sci., 121, 1727-1738, 2008.
3. Kyuuma M., Kikuchi K., Kojima K., Sugawara Y., Sato M., Mano N., Goto J., Takeshita T., Yamamoto A., Sugamura K., Tanaka N,: AMSH, an ESCRT-Ⅲ Associated Enzyme,Deubiquitinates Cargo on MVB/Late Endosomes. Cell Struct Funct., 31(2),159-172, 2006.
4. Tsukahara T, Agawa H, Matsumoto S, Matsuda M, Ueno S, Yamashita Y, Yamada K, Tanaka N, Kojima K, and Takeshita T.: Murine leukemia virus vector integration favors promoter regions and regional hot spots in a human T-cell line. Biochem Biophys Res Commun., 345(3), 1099-107, 2006.
5. Deborah Brancho, Nobuyuki Tanaka, Anja Jaeschke, Juan-Jose Ventura, Nyaya Kelkar, Yoshinori Tanaka, Masanao Kyuuma, Toshikazu Takeshita, Richard A. Flavell, and Roger J. Davis.: Mechanism of p38 MAP kinase activation in vivo. Genes Dev. ,17,1969-1978, 2003.
