分子病理学
概要
蛋白質、核酸に次ぐ第三の生命鎖である糖鎖は、細胞間コミュニケーションの担い手として様々な役割を演じています。私達の188bet体育_188bet备用网址室では疾患の病態形成における糖鎖の発現意義を明らかにするため、形態学、分子生物学、生化学、発生工学などの種々な技術を駆使して188bet体育_188bet备用网址を行っています。そして、最終的には疾患メカニズムの解明や新たな診断法、治療法の開発へと展開させたいと考えています。
188bet体育_188bet备用网址テーマ
1) 胃腺粘液糖鎖による胃癌発生の制御機構
2) 腫瘍における糖鎖並びに糖鎖関連分子の発現解析とその臨床病理学的意義
3) ヘリコバクター感染胃炎の分子病理
スタッフ
| 講師 | 川久保 雅友 |
|---|
188bet体育_188bet备用网址室の所在及び連絡先
教室の場所 ： 医学部基礎棟2階
主要な成果/Major Publications
- Kobayashi J, Kawakubo M, Fujii C, Arisaka N, Miyashita M, Sato Y, Komura H, Matoba H, Nakayama J: Cholestenone functions as an antibiotic against Helicobacter pylori by inhibiting biosynthesis of the cell wall component CGL. Proc Natl Acad Sci USA 118, e2016469118, 2021.
- Matoba H, Takamoto M, Fujii C, Kawakubo M, Kasuga E, Matsumura T, Natori T, Misawa K, Taniguchi S, Nakayama J: Cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice depends on cecum-specific mitogen-activated protein kinase pathway activation and inflammation. Am J Pathol 190, 453-468, 2020.
- Kawakubo M, Komura H, Goso Y, Okumura M, Sato Y, Fujii C, Miyashita M, Arisaka N, Harumiya S, Yamanoi K, Yamada S, Kakuta S, Kawashima H, Fukuda MN, Fukuda M, Nakayama J: Analysis of A4gnt knockout mice reveals an essential role for gastric sulfomucins in preventing gastritis cystica profunda. J Histochem Cytochem 67, 759-770, 2019.
- Ohya A, Yamanoi K, Shimojo H, Fujii C, Nakayama J: Gastric gland mucin-specific O-glycan expression decreases with tumor progression from precursor lesions to pancreatic cancer. Cancer Sci 108, 1897-1902, 2017.
- Kawakubo M, Horiuchi K, Komura H, Sato Y, Kato M, Ikeyama M, Fukushima M, Yamada S, Ishizone S, Matsumoto T, Ota H, Sagara J, Nakayama J: Cloning of Helicobacter suis cholesterol α-glucosyltransferase and production of an antibody capable of detecting it in formalin-fixed, paraffin-embedded gastric tissue sections. Histochem Cell Biol 148, 463-471, 2017.
- Yamanoi K, Sekine S, Higuchi K, Kushima R, Nakayama J: Decreased expression of gastric gland mucin-specific glycan α1,4-linked N-acetylglucosamine on its scaffold mucin 6 is associated with malignant potential of pyloric gland adenoma of the stomach. Histopathology 67, 898-904, 2015.
- Yamada S, Okamura T, Kobayashi S, Tanaka E, Nakayama J: Reduced gland mucin-specific O-glycan in gastric atrophy: A possible risk factor for differentiated-type adenocarcinoma of the stomach. J Gastroenterol Hepatol 30, 1478-1484, 2015.
- Shiratsu K, Higuchi K, Nakayama J: Loss of gastric gland mucin-specific O-glycan is significantly associated with progression of differentiated-type adenocarcinoma of the stomach. Cancer Sci 105, 126-133, 2014.
- Karasawa F, Shiota A, Goso Y, Kobayashi M, Sato Y, Masumoto J, Fujiwara M, Yokosawa S, Muraki T, Miyagawa S, Ueda M, Fukuda MN, Fukuda M, Ishihara K, Nakayama J: Essential role of gastric gland mucin in preventing gastric cancer in mice. J Clin Invest 122, 923-934, 2012.
- Kawakubo M, Ito Y, Okimura Y, Kobayashi M, Sakura K, Kasama S, Fukuda MN, Fukuda M, Katsuyama T, Nakayama J: Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection. Science 305, 1003-1006, 2004.