OutlookforstudentsaftergraduationDeveloping?the?genetic?resources?of?domestic?and?wild?silkworms?to?make?a?brand?of?silkOutlookforstudentsaftergraduationBiopolymers:?Gaining?an?understanding?of?the?function?and?structure?of?DNA?and?enzymes?in?order?to?explain?their?interactions?and?apply?them?to?biotechnology45Department?of?Applied?BiologyIamcarryingoutresearchintogeneticbreeding,ecdysisandmetamorphosis,andthegeneticrelationshipofthesilkwormtoitsrelative,thegiantsilkworm(naturalsilkworm).MylabcultivatesexcellentstrainsofnaturalsilkwormsinordertoreinvigorateJapan‘ssilkindustry.Thisisdonebysupportingtheraisingofnaturalsilkwormsinsilk‐producingregions.Mygoalistotrainnewtalentthatcancarryonthetraditionofcultivatingandproducingnaturalsilk.Thiswillcreateafuture,wheretheproductionofsilkandotheragriculturalproductsisreinvigoratedthroughacollaborationbetweenagriculture,business,andindustry.Graduatesgoontograduateschoolorworkattextileandfoodcompanies,JA,orlocalcompanies.Someserveasmiddleschoolteachersandpublicofficialsinagriculturalstudies.ProfessorZentaKajiuraProfessorKajiura'sacademiccredentialsareinagriculture,andhisareasofspecializationincludeagricultureandappliedentomology,moleculargenetics.Keywords:DNA,bio‐resources,breedingCocoons?and?silk?from?natural?silkworms.?The?cocoons?take?on?a?beautiful?green?color?that?is?unique?to?Japanese?cocoons.Isucceededinbreedingthelargewildsilkworm.Standardwildsilkwormsareshowninthetoprow.Thelargewildsilkwormisshowninthebottomrow.Iusuallyneedmorethan3000cocoonsofthestandardwildsilkwormtoget1kgrawsilk.However,Ionlyneedapproximately2000cocoonsifIusethelargesizewildsilkworm.Iexaminethenatureandstructureofnucleicacids,whichformDNA,carcinogensandactiveoxygen,whichdamagesDNA.MylabisalsoresearchingDNArepairenzymesthatrepairdamagedDNAfromacompletelynewperspectivewiththegoalofclarifyinghowrepairenzymesfinddamagedpartsoftheDNAandapplyingthisknowledgetoresearchintoanti‐carcinogenicdrugs.IfwecouldclarifythefunctionalstructureofDNAandenzymes,webelievethatknowledgecouldbeappliedinthemedicaldomainandeffectivelyusedintheindustrialproductionofbiologicalmaterials.Graduatesareactiveinresearchcentersatpublicresearchinstitutionsandcompaniesaswellasatfoodproductcompaniesandfermentedfoodcompanies,inthemedicaldomain,andatscientificpublishingcompanies.ProfessorToshioShidaProfessorShidajoinedtheFacultyofTextileScienceandTechnologyatShinshuUniversityin1986asaseniorassistantprofessorafterworkingasaresearchassociateattheNagoyaUniversityChemicalInstrumentCenterandasadoctoralresearcheratJohnsHopkinsUniversity.Hetookhiscurrentpositionin2009afterbecominganassociateprofessor.Hisareasofspecializationincludenucleicacidchemistry,proteinengineering,thescienceofbiopolymerproperties,andappliedmicroorganismengineering.Anexplanationofthesubstraterecognitionmechanismofvery‐early‐stageenzymesbeforetheformationoftheenzyme‐substratecomplex,somethingthathadnotpreviouslybeenconsideredforenzymesubstraterecognitionstructure.Farleft:TheenzymehasnotyetfoundthedamagedDNA.Center:TheaminoacidonthesurfaceoftheenzymehasfoundthedamagetotheDNA(intheformofahole).Farright:TheenzymeisattemptingtorepairthedamagedDNA.Outlook?for?research?Outlook?for?research?Department?of?Applied?BiologyDepartment?of?Applied?BiologyInitial complex formation stageAP endonuclease AP-DNA +AP endonucleaseAP site 『Recognizer: Tryptophan residue』AP site search tentaclesUltimate enzyme-substrate complexE. coliP. aeruginosaD strainR strainSEM Image: Membrane filter pore size 0.6 ?m
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