写真サイズ高さ4.35cm×幅3.6cm配置位置横15.3cm、縦2.85cmOutlook?for?research?Makingeffectiveuseofmicroorganismresources:DiscoveringandapplyingthepotentialcapabilitiesofBacillussubtilisOutlook?for?research?Toinvestigatethecharacteristicsofthebiologicalmaterial,todevelopanewmedicaldeviceNative?porcine?artery:?occlusionDecellularized?porcine?artery:?patent53応用生物科学科Department?of?Applied?Biology応用生物科学科Department?of?Applied?BiologyOutlookforstudentsaftergraduationOutlookforstudentsaftergraduationInordertodiscoverthenovelfunctionsandnetworksofthe4,100genesthatmakeuptheBacillussubtilisgenome,mylabiscooperatingwithdomesticandinternationalresearchlabstocarryoutmoredetailedresearch.WebelievethatB.subtilisisanimportantmicroorganismresource,andweareworkingtodevelopadeeperunderstandingofitspotentialsothatwecanutilizeit.Inthefuture,mygoalistoestablishararemetalrecoverysystemusingB.subtilisstrainswithalteredcellwallpolymers,tomakeeffectiveuseofthegeneticresourcesofitsclosestrelatives,andtoapplyassociatedtechnologytothedevelopmentofantibacterialagentsforpathogenicbacteria.Graduatesaretypicallyemployedbyfoodandpharmaceuticalcompanies.Somechoosetocontinuetheirresearchatdomesticandoverseasresearchorganizations.AssociateProfessorHirokiYamamotoAssociateProfessorYamamototookhiscurrentpositionin2007afterservingintheFacultyofTextileScienceandTechnologyatShinshuUniversityasanassistantprofessor.Hisareasofresearchincludemicrobiologytoexaminethepropertiesofmoleculesfunctioninginthecellsofmicroorganismsandappliedmicrobiologytomakeuseofthelatentcapabilitiesofmicrobes.A?student?uses?a?fluorescence?microscope?to?assess?the?effect?on?the?cell?when?cell?wall?polymers?are?modified.Astudentsearchesforbacterialsubstancesthatwillactivatetheimmunesystemofanimalcells.Wealsomakeobservationsusinganelectronmicroscopesowedonotmissslightchanges.Decellularizedtissuesarepreparedfrombiologicaltissues,andareclinicallyusedinEuropeandU.S.Thedecellularizedmaterialsshowbiocompatibilitiesatimplantedsites.Itispossibletotransplantanimaltissuestohumansbydecellularizationtreatments.Theobjectofourresearchisanapplicationandaninvestigationofthesedecellularizedtissuepropertiesforuseinmedicaldevices.Thevacuumpressureimpregnationtechniqueisabletoeasilyrehydratematerials.Ourresearchaimstofabricateanewmedicalmaterialusingthistechnique.Biologicalmaterialssuchasadecellularizedmaterialareabletomimiccomplexstructuresofanimaltissuesandcanbeusedasaremodelingmaterialbypatients’owncells.Itwouldbepossibletofabricatetissuesandorganinvitrobycombiningthesematerialsandstemcells.Usingotherfiledtechniquesmayleadanovelmedicaldevicefabrication.Studentslearntothinkbythemselvesandtakeinitiativeinthisresearchlab,andthispreparesthemtoworkbywellingroupsorbythemselves.Theyareequippedtopursuecareersacrossavarietyofscientificfields.AssistantProfessorJunNegishiAfterreceivingadoctorateinTokyoMedicalandDentalUniversity,AssistantProfessorNegisihworkedasaJSPSpostdoctoratSapporoMedicalUniversitybeforecomingADEKAasaresearchworker.Hisareasofresearcharebiologicalmaterials.(Left)Anativeporcinearteryafter3daysinratcarotidtransplantation.(Right)Adecellularizzedporcinearteryafter2weeksinratcarotidtransplantation(A)Afreeze‐driedaortaafter10minimmersionintoPEG.(B)Afreeze‐driedaortaafterPEGhydrationbyvacuumpressureimpregnation(VPI).TheVPItreatedaortashowedhomogeneousrehydration.
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