ACBDBCDCACucumberleafinfectedbyC.orbiculare(left).Fungalhyphalabelledwithgreenfluorescentproteininbiotrophicinvasivestage(right).Fungus-plantinteractionsAnthracnose diseaseColletotrichumChloroplast dynamicsEffectorKeywords:Animal Reproduction,Assisted Reproductive Technique (ART), ReproductiveTechnology,Gene Engineering,Neuro Science,Food Science.Plantpathogenicfungiareresponsiblefor70-80%ofallknownplantdiseases.Thus,plantprotectionespeciallyfromfungalpathogensisaverycriticalproblemforhumansociety.LaboratoryofMicrobe-PlantInteractionsisfocusingonthepathosystemsbetweenColletotrichumfungi,causalagentsofanthracnosediseases,andtheirhostplants.Understandingfungalpathogenicityandplantdefenseswillsupportdevelopmentofnewmethodsfordiseasecontrolandprevention.1.Developmentofnovelreproductivetechniquesrelatingtoinvitro2.Generationofanimalmodelsforhumandiseaseusingtransgenic3.Discoveringthefunctionalfoodingredientswhichhaveanti-agingthemolecularmechanismsOurlaboratoryhasthefollowingongoingprojects:folliculogenesis,IVM/F/C,andES/iPScells.andgenemodifyingtechniques.effectsonsomaticstemcells.Invitrogrowthofisolatedovarianfolliclesisanemergingtechnologyforfertilitytreatment.Novelreproductivetechniqueswillprovidesolutionsfortheproblemofinfertilityinhumanandpoorreproductiveefficiencyindomesticanimals.Inmedicalresearch,manykindsoftransgenicanimalshavebeenproducedtomodelhumandiseaseandtheyprovideindispensabletoolsstudyingdiseasemechanismsandtherapiesinvivo.Tomaintainourhealth,preventivemedicinehasattractedalotofattentioninrecentyears.Theoneofmostimportantfactorsinpreventivemedicineisfoodenvironments.Discoveringthefunctionalfoodwillcontributetohumanhealth.Novel chloroplast response induced by non-adapted Colletotrichumfungi in plant epidermis.Molecular basis of infection strategy in plant pathogenic Colletotrichumfungi.Development of new methods for control of anthracnose diseases.underlying33forTosuccessfullyinfectaplant,fungalpathogens(e.g.Anthracnosefungi)suppresshostimmunity.Fig. 1.Microscopy with micromanipulator (left) and manipulation of mammalian embryo (right).Fig. 2. Common marmoset (left) and its embryonic stem cells (upper right), induced pluripotent stem cells (lower right).HirokiIRIEDAAssociate Professor, Ph.D.IkuoTOMIOKAAssociateProfessor,Ph.D.1.Developmentofnovelreproductivetechniques.2.Generationofanimalmodelsforhumandisease.3.Discoveringthefunctionalfoodingredients.Biotechnology DivisionBiotechnology DivisionLaboratory of Microbe-Plant InteractionsLaboratory of Applied Reproductive Science
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