47Department ofDepartment ofWearecarryingoutresearchtogainadeeperunderstandingofthestructureandfunctionofproteinsandtodesign,develop,andapplyusefulartificialandengineeredproteins.Inthefieldsofproteindesignandengineering,ourlabusescuttingedgetechnologytosee,analyze,create,andapplyusefulproteins.Outlook for researchInthefuture,mygoalistoestablishararemetalrecoverysystemusingB.subtilisstrainswithalteredcellwallpolymers,tomakeeffectiveuseofthegeneticresourcesofitsclosestrelatives,andtoapplyassociatedtechnologytothedevelopmentofantibacterialagentsforpathogenicbacteria.Outlook for students after graduationGraduatesaretypicallyemployedbyfoodandpharmaceuticalcompanies.Somechoosetocontinuetheirresearchatdomesticandoverseasresearchorganizations.Outlook for researchOurgoalistoapplyproteinsinvariousfields,forexampleinbiotechnologyandpharmaceuticaldevelopment,inordertodevelopeco-friendlyhighlygreenchemistrycatalysts,high-sensitivitybiosensors,andeffectivevaccines.Intheseways,wehopetocontributetheachievementofasustainablesociety.nanomaterials,functionalOutlook for students after graduationGraduatesareemployedinnumerousfields,includingfood,pharmaceutical,optics,chemical,andbiochemicalcompanies.atInordertodiscoverthenovelfunctionsandnetworksofthe4,100genesthatmakeuptheBacillussubtilisgenome,mylabiscooperatingwithdomesticandinternationalresearchlabstocarryoutmoredetailedresearch.WebelievethatB.subtilisisanimportantmicroorganismresource,andweareworkingtodevelopadeeperunderstandingofitspotentialsothatwecanutilizeit.ProfessorYAMAMOTOHirokiProfessortookhiscurrentpositionin2023afterservingintheFacultyofTextileScienceandTechnologyatShinshuUniversityasanassistantprofessorandassociateprofessor.Hisareasofresearchincludemicrobiologytoexamineofmoleculesfunctioninginthecellsofmicroorganismsandappliedmicrobiologytomakeuseofthelatentcapabilitiesofmicrobes.AssociateProfessorARAIRyoichiAssociateProfessorAraijoinedShinshuUniversityin2007afterworkingasaresearcheratRIKENandPrincetonUniversityintheU.S.Hisareasofresearcharestructuralbiologytoanalyzethethree-dimensionalstructureandfunctionproteinofengineeringusefulproteinsthroughtheirmodificationanddesign.Yamamotothepropertiesproteins,toanddevelopAstudentsearchesforbacterialsubstancesthatwillactivatetheimmunesystemofanimalcells.A student uses a fluorescence microscope to assess the effect on the cell when cell wall polymers are modified.Anexperimentintheresearchlab(upperleft),productionofusefulproteinswithmicroorganisms(upperright),proteincrystalswhichshinelikeapreciousstone(lowerleft),andanX-raydiffractionexperimentatasynchrotronradiationfacility(lowerright)Self-assemblingnanoarchitecturesarecreatedfromaproteinnano-buildingblockbyfusingadimericdenovoproteinWA20andatrimericfoldondomainfromT4phage.(Kobayashi,N.etal.,J.Am.Chem.Soc.,137,11285-11293,2015)Wealsomakeobservationsusinganelectronmicroscopesowedonotmissslightchanges.Applied BiologyApplied BiologyDesigning and developing useful proteins by studying the structure and function of proteinsMaking effective use of microorganism resources: Discovering and applying the potential capabilities of Bacillus subtilis
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