BDACABC8?FoodfunctionalityofeggplantEggplantabundantacetylcholinethantheothervegetablesandisexpectedfoodfunctionalitiesbyregulatingautonomicnervousactivity.?LC-MS/MSCholine estersin foods aredetermined by using LC-MS/MSin our original method. Laboratory of Synthetic Natural Products ChemistryTheresearchinourgroupfocusesaroundthechemistryofbiologicallyactivenaturalproducts:synthesis,structure-activityrelationships,biosynthesis,biosyntheticinhibitors,structureelucidation.Developmentofnovelchemicalreactionusingorganometallicsisalsostudied.Synthesis of biologically active polyphenolsWehavegreatinterestinpolyphenolsbecauseoftheirpotentbiologicalactivities.Thus,wehavesynthesizedthesemoleculesforanalysisoftheirstructure-activityrelationships.Synthesis of natural products using organometallicsStereoselective aminopalladation and oxypalladation are very important approaches for the synthesis of various natural products which contain N-and O-hetero-alicycles. We accomplished the synthesis of natural products using Pd(II)-catalyzed stereoselective cyclization.Food Science and Biotechnology DivisionFood Science and Biotechnology DivisionLaboratory of Food Molecular EngineeringHidefumiMAKABEProfessor,Ph.D.Kozo NAKAMURAAssociate Professor, Ph.D.Functional Foods, Choline Esters, Peptides, Polyphenols, Antihypertensive FoodsNot activeactiveKeywords:organicsynthesis,naturalproducts,bioactivecompounds,Structure-activityrelationships,organometallicsTheLaboratoryofFoodMolecularEngineeringconductsresearchonutilization,quantificationandisolatedpurificationoffunctionalmoleculesinfoodandfoodresources.Cholineesters,peptidesandpolyphenolsaremaintargetcompounds,andwefocusontheireffectsonthecardiovascularsystemandnervoussystem.FoodproductsfromtheShinshuregionsuchas“fermentedfoods”,“buckwheat“and“medicinalplants”arerichinthesefunctionalmolecules.Recently,wefoundthat“eggplant”wasrichinacetylcholineanddemonstratedbloodpressureandmoodimprovementeffectsinaclinicaltrial.Foodmolecularengineeringmakesthefoodfunctionalitiesmoreeffectiveandincreasestheutilityvalue.containsmuchmoreisolationandNMR is essential tool to elucidate the structure of organic compounds.AlcetylchoineAntitumor activity of procyanidin B3 and prodelphinidin B3 against human PC-3 prostate cancer cell lines. Prodelphinidin B3 which has pyrogallol moiety (red colored) possesses significant activity.Structural elucidation using NMR（写真一枚or複数枚組み合わせ）CholineestersareNOVELfoodfunctionalfactors.WearethefirsttoisolatethenaturalLactoylcholine.Alcetylchoineis known as our neurotransmitter. The content in eggplant is 3 mg/100g F.W in average. No one knows why eggplant contains so much acetylcholine.AcetylcholineLactoylcholinePropionylcholineButylylcholine
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