BBDCNozawanaTLRsDendritic cellsResveratrol (Res)Immunostimulatory effectChanges in bacterial flora and immunoregulatory effectsNozawanaNozawanapickle++?+11Food Science and Biotechnology DivisionTheresearchinterestsoftheLaboratoryofFoodSciencefocusonthediscoveryanddevelopmentofNutraceuticalsandnovelactivecompoundsthatcanbeusedfordrugsorfunctionalfoods.Inaddition,wechallengetoidentifymoleculartargetsoffoodfactorsthatareeffectiveagainstobesityandits-associateddiseases.Ourlaboratoryaimtodevelopcreativescientistthatcontributestosocietythroughresearchandeducation.Food Science and Biotechnology DivisionLaboratory ofFood FunctionLaboratory of Food ImmunologyObesityisoneoftheriskfactorsfortype2diabetesandcardiovasculardiseases,andalsodementia.Thus,wefocusonobesitytopreventtheabove-mentioneddiseases.Analysisofmolecularmechanismofanti-obesitytheidentificationofthemoleculartargetsoftheseactivecompounds.compounds,activeDevelopment of a therapeutic agent for obesity and obesity-associated diseases.SachiTANAKAAssociateProfessor,Ph.D.TakakazuMITANIAssociateProfessor,Ph.D.Variousbacteria Immune cellsDifferentiation to adipocytes3T3-L1 cells are model of adipocytes. We have searched the anti-adipogenesis and anti-obesity compounds using this cells.Furthermore, we have characterized molecular target in adipocytes for active compound against obesity.Fermentation of NozawanaLactic acid bacteria Cell lysatesRes-bound resinKeywords;FoodimmunologyDendriticcellsTcellsIFN-gammaResearchkeywords:Obesity-associateddiseases,Adipogenesis,Adipokines,AdipocytedifferentiationFoodfactors,Foodfunctions,Weareplanningtoexaminetheeffectsoffoodcomponentsanddietaryhabitsonimmunefunctionsandelucidatemolecularmechanismsofimmuneregulation.Moreover,weareaimingfortheinvestigationofunknownimmune-modulatingeffectsofcompoundsderivedfromfoods,andidentificationoffunctionalcomponentstopreventimmune-relateddiseasessuchasinfectiousdisease,cancer,andallergy.Thesestudieswillleadtoapplicationforfunctionalfoodsexhibitingimmuneregulatingeffects.Immunostimulatory effects of NozawanaBrassicarapaL.,knownasNozawanainJapan,isacruciferousplantandatraditionalvegetableoftheShinshuanimmunostimulatoryeffectbyenhancinginterferongammaproductionandnaturalkilleractivity.DuringthefermentationofNozawana,thenumberoflacticacidbacteriaincreasedandcytokineproductionbyspleencellsisenhanced.Thus,Nozawanacouldbeapromisingfoodforimprovinghumanhealth.area.NozawanaImmuneregulationbydietarypolyphenolsProcyanidin,adietarypolyphenolispresentinfood.WehavereportedthatPCB23,3′′-di-O-gallate(PCB2DG),whichcontainstwogallategroups,markedlyinhibitedtheproductionofproinflammatorycytokinesfromimmunecells.Furthermore,wehaveshownthatPCB2DGamelioratedtheinflammatorydiseasesusingmousemodels.exertedcompound,andIFN-gIL-12NK activityCytokineInputPull down+++Res
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