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ACucumberleafinfectedbyC.orbiculare(left).Fungalhyphalabelledwithgreenfluorescentproteininbiotrophicinvasivestage(right).ACBDBCDC30Biotechnology DivisionBiotechnology DivisionLaboratory of Microbe-Plant InteractionsLaboratory of Applied Reproductive ScienceHirokiIRIEDAAssociate Professor, Ph.D.IkuoTOMIOKAAssociateProfessor,Ph.D.1.Developmentofnovelreproductivetechniques.Invitrogrowthofisolatedovarianfolliclesisanfertilitytreatment.Novelemergingtechnologyforreproductivetechniqueswillprovidesolutionsfortheproblemofinfertilityinhumanandpoorreproductiveefficiencyindomesticanimals.2.Generationofanimalmodelsforhumandisease.Inmedicalresearch,manykindsoftransgenicanimalshavebeenproducedtomodelhumandiseaseandtheyprovideindispensabletoolsstudyingdiseasemechanismsandtherapiesinvivo.3.Discoveringthefunctionalfoodingredients.Tomaintainourhealth,preventivemedicinehasattractedalotofattentioninrecentyears.Theoneofmostimportantfactorsinpreventivemedicineisfoodenvironments.Discoveringthefunctionalfoodwillcontributetohumanhealth.Fungus-plantinteractionsAnthracnose diseaseColletotrichumChloroplast dynamicsEffectorKeywords:Animal Reproduction,Assisted Reproductive Technique (ART), ReproductiveTechnology,Gene Engineering,Neuro Science,Food Science.Plantpathogenicfungiareresponsiblefor70-80%ofallknownplantdiseases.Thus,plantprotectionespeciallyfromfungalpathogensisaverycriticalproblemforhumansociety.LaboratoryofMicrobe-PlantInteractionsisfocusingonthepathosystemsbetweenColletotrichumfungi,causalagentsofanthracnosediseases,andtheirhostplants.Understandingfungalpathogenicityandplantdefenseswillsupportdevelopmentofnewmethodsfordiseasecontrolandprevention.themolecularmechanismsOurlaboratoryhasthefollowingongoingprojects:1.Developmentofnovelreproductivetechniquesrelatingtoinvitrofolliculogenesis,IVM/F/C,andES/iPScells.2.Generationofanimalmodelsforhumandiseaseusingtransgenicandgenemodifyingtechniques.3.Discoveringthefunctionalfoodingredientswhichhaveanti-agingeffectsonsomaticstemcells.Novel chloroplast response induced by non-adapted Colletotrichumfungi in plant epidermis.Molecular basis of infection strategy in plant pathogenic Colletotrichumfungi.Development of new methods for control of anthracnose diseases.underlyingforTosuccessfullyinfectaplant,fungalpathogens(e.g.Anthracnosefungi)suppresshostimmunity.Fig. 1.Microscopy with micromanipulator (left) and manipulation of mammalian embryo (right).Fig. 2. Common marmoset (left) and its embryonic stem cells (upper right), induced pluripotent stem cells (lower right).

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