?Stem cell biology?Skeletal muscle?Myogenic differentiation?Regenerative medicine?Transcription factorABCDBCA4Laboratory of Molecular Cellular BiologyHiroshi MASUMOTOAssistantProfessor,Ph.D.Tomohide TAKAYAAssociate Professor, Ph.D.Integrated Bioscience DivisionLaboratory of Applied Mycology and Mushroom ScienceIntegrated Bioscience DivisionResearch keywords:MycologyFungal biologyMuscledistinguishesanimals.Wecanmoveaswewantbymusclefunctions.Higheranimalshavethreetypesofmuscles;cardiac,smooth,andskeletalmuscles.Ourmovementscanberealizedbycooperationofthreemuscles.Thesemusclecellsareverysimilar,inthesameway,quitedifferent.Oneofourinterestsisthemechanismwhichenablesmusclediversity.Forhealthylongevity,allmusclesshouldbemaintainedhealthful.Wearechallengingtounderstandthemolecularandcellularmechanismsofmuscularhomeostasis,regeneration,anddiseases.Morethan100,000speciesoffungi,includingmushrooms,areknowntoscience.However,withtheexceptionofafewwell-knownfungiandmushrooms,onlyafewfungihavebeenactivelystudiedoutsideoftaxonomy,andonlyafewhavehadtheirfunctionsinvestigatedorexploited.Inourlab,ourfirstpriorityistofindandgrowthefungusthateachofuswantstostudyinthefield.Ourgoalistoevaluatethedifferentcharacteristicsofthesecultivatedisolates,tosearchfornewcharacteristicsnotyetknowntotheworld,andtomakefulluseofthebiologicalresourcesoffungi.Wearefocusingonskeletalmusclestemcells,satellitecells,whichenabletorobusttheregenerativecapacityofskeletalmuscle.Oursubjectsare;1.Researchonthemechanismofskeletalmuscleregeneration.2.Developmentofthefoodsanddietstopreventmusclediseases.3.Establishmentofthetechnologyforartificialmuscleandmeat.Ourresearchisgoingonthefieldsofagriculturalbiological,andmedicalscienceswiththefinetechniquesofstemcellbiology.Fungal symbiontAlgal symbiontResearch on the mechanism of fungal-algal symbiosis using a basidiolichen Multiclavula mucidaas a model organism.FieldsamplingElucidation of the molecular basis of fungal-algal symbiosis through de novo assembly and expression of symbiotic genes.In vitro re-synthesisIsolationCultivationGenomicextractionCultivation of underutilized mushroomsWe are working on the cultivation of underutilized edible mushrooms.e.g., Hypholoma, MorchellaFunga of ShinshuShinshu is blessed with rich mountain forests that support a wide variety of fungi. We are making an inventory survey of these fungi.Fungi in symbiosis with algaeWe are investigating the genetic background of the symbiosis between fungi and algae.Day 0Day 1Immunostainingofskeletalmusclestemcellsduringmyogenicdifferentiationinculture.Bioinformaticanalysisofbindingsitesofmyogenictranscriptionfactors.Day 2Day 3thegenome-wideDNA-
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