MaterialsChemistryMaterialsChemistry15YasunoriTodaWearetryingtofindusefulenzymesfrommicrobes,andutilizethemtodecomposebiomass.Biomassisarenewableresourceandisdegradedbymicrobialenzymesinnature.Thisdegradationisaveryefficientsystemthemicrobeshavedevelopedintheprocessofevolution.Inordertousethisforourtargetreaction,enzymesmustbeisolatedandtheirstabilityandactivitymustbeimproved.Wouldyouliketojoinourteamtoexploretheabilityofmicrobialenzymesanddevelopbiomassutilization?KouichiNozakiIn the FutureAfter GraduationIn the FutureAfter GraduationOurgroup’sinterestisthedesignanddevelopmentofneworganicmolecules.Thereareanumberoforganiccompoundsinyourlife-smallmoleculesinmedicinalandagriculturalchemistrytolargemoleculesinmaterialscience.Organicsynthesisisanessentialtoolforbothacademiaandindustry,andinordertofacilitatefurtherdevelopmentoforganicchemistryweshouldcontinuetryingtocreateandunderstandnewmoleculesandtheirreactivity.Ourgroupfocusesoncatalysisdevelopmentbecausethebehaviorofnewmoleculescanbeevaluatedbytheresultsofcatalyticreactions.AssociateProfessorPh.D.: Tohoku Univ.Postdoc: Vanderbilt Univ.Assistant Professor:Shinshu Univ.He promoted an associate professor in Apr 2020.His research focuses on catalysis development. Associate ProfessorPh.D.2005-Associ. Prof. Research fields: Biological chemistry and Genetic engineering of enzymes. The scientific research and its application of microbial enzymes.Duetotheexpansionofscienceandtechnology,furtherprogressinorganicsynthesishasbeenrequired.Ingeneral,achemicalreactionprovidesnotonlyadesiredproductbutalsoundesiredproducts.Webelievethatcatalysisgovernsorganicreactions,leadingtoselectiveproductformation.Ourcontinuouseffortsonthedevelopmentofefficienttransformationswouldcontributetoindustryaswellasacademicresearchinthenearfuture.Organicchemistscanworkinseveralfields,thusmanyformergroupmembersarenowinpharmaceutical,agrochemical,andchemicalcompanies.Ourstudentscanlearntosolveproblemsthroughexperienceinthelabwhichshouldbevaluabletonumerousjobseventhoughtheyarenotrelatedtochemistry.Thereareinfinitetypesofmicrobesandmostofthemareunidentified.Amongthem,theremaybeanavailableonewhichproducesusefulenzymesforhumanbeings.Inourlab,weusegenemanipulationtoincreaseenzymeproductivityandimproveenzymefunction.Enzymescatalyzethespecificreactionundermildconditions.Biomassandenzymeswillplayanincreasinglyimportantroleaswetrytoestablishasustainablechemicalprocess.Enzymeshavebeenusedinthefieldsofchemistry,medicine,food,agriculture,andfibers.Theexperimentaltechniquesthestudentslearninourlab.willbeusefulinthefieldsofchemistryandbiology.Inordertodomoreadvancedresearch,somestudentsgoontograduateschools.Trial and error leads to optimized reaction conditions. These reactions are run in an oil bath to maintain the temperature. Selectivity of catalytic reactions is measured by the use of High Performance Liquid Chromatography (HPLC). Aspergillusoryzaeproducingrecombinantfrommushroom.DNAextractiontouseforgenemanipulation(left),Isolationofmicrobeasepticallyincleanbench(right).Celluloseinplantcellwallvisualizedfluorescentprotein.enzymebyCreation and Understanding of New Molecules and their Reactivity though Catalysis DevelopmentDegradation and Utilization of Biomass！?Improvement of enzyme by gene manipulation technique?
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