（チーフ：特任教授?高本雅哉）Stomach cancer in N-acetylglucosaminyl transferase-deficient miceColon cancer in arylhydrocarbonreceptor-deficient miceLy6CLy6GF4/80Fig.1 Analysis of immune cell populations in the spleen in mice, separated by4 parameterflowcytometrytechnique. (yellow: neutrophils, light blue: monocytes, light green: macrophages, pink: dendriticcells).Wild-type miceFig.2 T lymphocyte subpopulations in the intestinal epithelia in mice made deficient in a gene (yellow:TCRαβ Tcells, light blue: TCRγδT cells). NotethatTCRαβT cellsare absent in the mutant mice (right). TCR?CD8?TCR?CD8?TCR??TCR??CD11cMutant mice5寄生虫感染症学教室Immunological and pathological research ParasitologyProf. Masaya TakamotoMolecular and 免疫制御学cellular immunologyon chronic inflammationHow the immune system is built up and works rightlyAchronicinflammationwasfindingoutinrecentyearstoberesultedincancer,lifestyle-relateddiseases,aneurodegenerationdiseases,autoimmunediseasesetc.Usingknockoutmice,weareexploringthepathogenesisoftumorsandautoinflammatorydiseasesandonsetfactors.Oneofourbody’sactivitiesessentialtolivehealthyistheimmunesystem.Thissystemhastoworkproperly,andwithtooweakimmunitywearevulnerabletoinfectionsandcancers,whiletoostrongimmunityleadstoallergiesandautoimmunediseases.Inordertounderstandhowtheimmunesystemworks,ourlaboratorypursuesthemechanismsbywhichtogeneratevariouscellsintheimmunesystemandtomakethemworkappropriately.Thesestudieswillcontributetothepreventionandcureofvariousdiseases.timely fashion. ?Signal transduction molecules that convey various intracellular signals for the functions of immune cells.Research subjectRelationshipbetweencoloncanceronsetandintestinalbacteria.Immunologicalanalysisofautoinflammatorydiseases.Relationshipbetweenthefunctionofmucosalsugarchainandinfectiousdiseaseindevelopinggastriccancer.Outlook for researchCausesofillnessareinheritedandacquired.Analysisusinggeneticallymodifiedmicehasrevealedthatgeneticabnormalityisnotdirectlycausingcarcinogenesisbutcausesinflammation.Furtherleadingtothedevelopmentofnewtreatmentsandpreventivemethods.Outlook for students after graduationResearcher.Incaseofmedicaldoctors,mostofthepostgraduatestudentshavebeenbacktotheirownfields.Research subject?Transcription factors for switching various genes in immune cells on/off in a Outlook for researchToday,inthefieldofimmunology,growingnumbersofnewtherapiesarebroughtforthforcancersandimmune-relateddiseasessuchasrheumatoidarthritis.Alsouncoveredrecentlyisthecontributionoftheimmunesystemtotheregulationofgoodrelationshipbetweenourhealthandbacterialivinginthegutandskin.Deeperunderstandingoftheimmunesystemwillhenceprovideuswithvaluablehintsonnotonlyimprovementofdiseasediagnosisandtherapies,butalsobetterlifestylestokeepourselveshealthy.Outlook for students after graduationByacquiringbasicknowledgeandgainingpracticalskillsinimmunologyinourlaboratory,graduatesareexpectedtobeclinicianswhohavescientist’seyesandcontinuouslyask‘why’and‘how’alsoinclinics.researchwillbeaimedat
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