We evaluated the reduction of intensity of PiB-PET in heart after complete regression with chemo-theraphy(Oguchi、Katoh.Amyloid 2023）We revealed the progression of ATTR cerebral amyloid angiopathy by using PET（TakahashiAmyloid 2023）Upper: Amyloid deposition in endocrine tumor and peptide gained by LMD was part of somatostatinLeft Lower: the methods of LMDWe revealed the novel amyloidosis of somatostatin by using Laser micro dissection(LMD) and tandem LC-MS（Ichimata、KatohAmyloid 2022）M：月MedicineⅢMedicineⅢAmyloidosis12(Neurology and Rheumatology)?SummaryofActivity?ChiefChiefofNeurology:YoshikiSekijima(professor)ChiefofRheumatology:YasuhiroShimojima(associateprofessor)?DivisionChief：prof.YoshikiSekijimaResearch subjectOutlook for students after graduationThebothwaystoabrilliantfutureasgeneralistand/oramyloidosisspecialistareprovided.Explore the whole body!Be generalist with specialized skills!Leading amyloidosis center in JapanDepartmentofMedicine(NeurologyandRheumatology)isfocusingonthedevelopmentofskillstoexplorethepatients’wholebody.IntheNeurologyarea,ourtargetistotalnervoussystemofthewholebodywhichconsistofthebrain,spine,peripheralnerve,andmuscles.Therearemanyneurologicaldisorderswhichdonotshowanyabnormalityinbloodtestsorimagingexamination.Thereforeitisveryimportanttomakeacorrectdiagnosisthroughthewholebodyphysicalexaminationsandneurologicalexaminations.IntheRheumatologyarea,weseethepatientswithconnectivetissuedisorderswhichmainlyinvolvethewholebodyjoints.Youmightbeabletogettheabilitytofindabnormaljointsbytouchingandfeelingthepatients’jointsbyyourownhands.Amyloidosisisadisordercharacterizedbythedepositionofabnormalproteincalled‘amyloid’intothewholebody,suchasthebrain,heart,kidney,liver,digestivetract,peripheralnervoussystem,muscles,andendocrinesystems.Thesevisceralorgansarealsoinvolvedamongthepatientswithrheumaticdiseases.Therefore,youmaygetthespecializedskillsasanneurologistandrheumatologistandalsogetthegeneralskillstoseeandmanagethepatients’wholebodyissue.Seefollowingpagestocheckthedetailsofourresearchworks.Amyloidosisisanintractablediseaseinwhichabnormalprotein,called‘’amyloid’’,depositintomultivisceralorgansandcauseorgandysfunction.Itissometimesverydifficulttodiagnoseand/ortreatamyloidosisappropriately.Ourdepartmentisoneoftheleadingamyloidosiscenterinthenation,providingtotalservicessuchasdiseaseconsultation,diagnosis,research,andtreatment,especiallyinthefieldoftwomajortypesofamyloidosis,ATTRandALamyloidosis.?Evaluation of Disease-Maker and pharmacological treatment for ATTRmamyloidosis.?AL amyloidosis treatment using novel chemotherapeutic agents.?Development of whole body amyloid imaging technique using PiB-PET .?Neurophysiological evaluation and analysis of amyloid neuropathy.?Detection of rare types of amyloidosis using laser micro dissection and mass spectrometry.Outlook for researchMuchcommondiseasessuchasAlzheimerDiseaseandtype2diabetesareotherkindsofamyloidosis.Ourresearchworksmightleadtounveilingandovercomingofthesepopulardiseasesaswellasakindofraretypesofamyloidosis.1.Amyloidosisteam2.BrainDiseaseResearchteam3.Musclediseaseresearchteam4.Rheumatology,Clinicalimmunologyteam2024-2025医学科188bet体育_188bet备用网址紹介
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