主な188bet体育_188bet备用网址テーマ?SummaryofActivity?DivisionsTanriShiozawa,M.D.,Ph.D.Chief: Assoc. Prof. Tsutomu MiyamotoResearch subjectOutlook for researchOur research results will hopefully contribute to the development of new prevention and treatment methods. Hence, we aim to reduce the incidence of these cancers and improve treatment outcomes.Outlook for students after graduationAfterobtainingaPh.D.degree,youcanstudyabroadatforeigncountriessuchasJohnsHopkinsUniversityintheUSandweactivelysupportyourfurthersuccess.産科婦人科学教室Gynecologic Cancer Group30Obstetrics and GynecologyObstetrics and GynecologyFrom birth to the end of lifeRevealing and curing refractory gynecological cancersMembers of our DepartmentProf.TanriShiozawaMembers of the Gynecologic Cancer Group“Come on and join us!”Dr. David H. Mvuntawas a foreign graduate student from Tanzania (from 2013 to 2017). He worked hard and obtained a Ph.D.here.SGI-1776(Pim1inhibitor)significantly reduced the proliferation of USC cells. (red line).HE staining of GASObstetricsandGynecology(ObGyn)encompasses4majoracademicfields:Obstetrics,GynecologicOncology,ReproductiveMedicine,andWoman’shealthcare(Fig.1).ObGynisthemedicalfieldthatsupportswomenthroughouttheirlifetime,frombirthtotheendoflife.Theuterusandovaries,whicharespecifictofemales,markedlychangethroughouttheirlifetime.Pregnancyanddeliveryarethemostdramaticchanges,inwhichnormalandabnormalconditionsmaysequentiallyoccur.WewanttoobtainaclearerunderstandingofthesechangesanddiseasesspecifictowomenandalsoperformmedicalexaminationsusingnotonlyObGyn,butalso,forexample,embryology,pathology,anddiagnosticimaging.Althoughmedicaltechnologieshaverapidlyadvanced,manyissueshaveyettoberesolved.Amonggynecologiccancers,themorbidityandmortalityofendometrialandovariancancersarerapidlyincreasinginJapan.Therefore,themechanismsunderlyingendometrialandovariancarcinogenesis/progressionneedtobeelucidatedandnewtreatmentandpreventivemethodsdevelopedbasedonthesemechanisms.Duetoadvancesinperinatalmedicine,Japanhasbecomethesafestcountryforpregnancyanddelivery.However,theonsetmechanismsofhypertensivedisordersofpregnancy(HDP)andintrauterinegrowthrestriction(IUGR),whichmarkedlyaffectperinataloutcomes,remainunclear.Althoughadvancesinassistedreproductivetechnologiessuchasinvitrofertilizationandembryotransfer(IVF-ET)havealsobeenachieved,manyissues,suchasincreasesintheincidenceofchromosomalabnormalitiesandmalformations,havetobeovercomeinthefuture.Eachofourdivisionsareactivelyconductingresearchtoaddresstheseissues.?Professor1.GynecologicCancerGroup2.PlacentaGroup3.ReproductionGroupWeareconductingresearchonrefractorygynecologicalcancers(ovarianclearcellcarcinomaOCCC,uterineserouscarcinomaUSC,andgastrictypeadenocarcinomaofthecervixGAS).NewcandidategenesassociatedwiththepathogenesisofOCCCweredetectedandfoundtobeapotentialtargetfortherapy.Wehaveestablishedtheworld‘sfirstmousemodelthatdevelopsendometriosis-relatedcancerbyknockingoutARID1AandPTEN,andnowanalyzingthecarcinogenicprocessofendometriosiswiththismodel.Focusingontheproto-oncogenePIM1,whichcorrelateswiththeprognosisofUSCshowingrapidprogressionandresistancetotreatment,wehavedemonstratedtheefficacyofPim1inhibitorsagainstUSCinvitroandinvivo.WehaveextensiveexperienceinGAS,whichhasapoorprognosisandisdifficulttodiagnoseatanearlystage,andinthesimilarbenignlesion,lobularendocervicalglandhyperplasia(LEGH),andareleadingtheworldinbasicandclinicalresearch.Ouroriginalpreoperativeanalyticaldiagnosismethodhasbeenestablished,andweareworkingtodevelopnewtreatmentmethods.?Development of novel PIM1-or CCNA-targeted therapy for endometrial cancer?Elucidation of the pathogenesis of refractory ovarian cancer?Clarification of the carcinogenesis of GAS and development of specific therapies2024-2025医学科188bet体育_188bet备用网址紹介
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