?ImprovementoffertilitypreservationmethodsfortheAdolescentandYoungAdult(AYA)?CulturingofimmatureoocytesretrievedfromexcisedovariesOutlook for researchWehopethatthatourresearchresultsleadtotheautomaticsortingofgoodsperm,improvedspermselectionaccuracy,and,thus,reductionsintheincidenceofchromosomalabnormalities.Improvementsinfertility-preservingtechnologiesforpatientswithAYACancermayenhancetheirmotivationincancertreatments.信州大学医学部医学科発行年月：２０２４年７月発行：信州大学医学部31Chief: Senior Assistant Professor Research subject?Investigation of the effects of LCN2 and LCN2-related factors on EVT?Research on the mechanisms responsible for placental aging?Investigation of the utility of NRG1 as a diagnostic marker for fetal lung maturation?Research on the therapeutic effects of macrolide antibiotics in preeclampsiaOutlook for researchWe hope that our research results lead to the establishment of screening and prevention methods for high-risk cases of HDP and IUGR. Our research results may lead to improvements in neonatal prognoses by establishing preterm birth prediction and prevention methods and promoting fetal lung maturation.Outlook for students after graduationAftergraduatingandobtainingaPh.D.degree,foreignstudentshavereturnedtotheirowncountryorworkedintheUSAaspostdoctoralfellows.Chief: Assistant Professor Shotaro HiguchResearch subject?ResearchaimingtoestablishamethodforeffectivespermselectionbasedonspermOutlook for students after graduationAftergraduatingandobtainingaPh.D.degree,foreignstudentshavereturnedtotheirowncountryorworkedintheUSAaspostdoctoralfellows.Obstetrics and GynecologyObstetrics and GynecologyPlacenta GroupReproduction GroupNorihiko Kikuchi The placenta is amysterious organSupporting fertility in the Present and FutureMembers of the PlacentaGroupEarly placental tissue immunostainedby CK7, a marker for EVT, showed the infiltration of EVT. Cell cultures are a basic experimental technique that is indispensable for functional analyses. Members of the Reproduction GroupDuring the selection of morphologically normal spermTheplacentaisinvolvedinnotonlytheexchangeofoxygen,nutrients,andwaste,butalsoinhormoneproductionandimmunity.Thesefunctionsaffectfetalgrowthandthemaintenanceofpregnancy,buthavenotyetbeenelucidatedindetail.Theinsufficientinvasionofextravilloustrophoblasts(EVT)tothemyometriumduringplacentalformationinearlypregnancyisamajorcauseofhypertensivedisordersofpregnancy(HDP)andintrauterinegrowthrestriction(IUGR),whichsignificantlyimpairmaternalandfetalhealth.Therefore,wefocusonfactorsthatregulatetheinvasionofEVT.WepreviouslyreportedthatLCN2,anirontransporter,promotedtheinvasionofEVT.Furthermore,amongvariousbiologicallyactivesubstancessecretedfromtheplacenta,suchashormones,wehaveinvestigatedNRG1asafactorpromotingfetallungmaturation.Wealsoexaminedthesenescenceoftrophoblasticcellsintheplacenta,whichmayregulategestationalageinapproximately280days.In Japan, more couples are facing infertility due to delaying marriage and childbirth. Assisted reproductive technologies such as IVF, ICSI, and embryo transfer provide hope for couples who desire children. Recent reports showing a decrease in male sperm counts emphasize the importance of ICSI. While effective sperm selection is vital for improving fertilization rates and reducing abnormalities, it currently depends on experience rather than clear criteria. Our research suggests the potential to identify viable sperm through mathematical analysis of morphology. Moreover, preserving fertility in adolescent and young adult (AYA) cancer patients is critical. Our success in developing techniques for retrieving and culturing immature oocytes from excised ovaries in ovarian cancer cases enables both cancer treatment and fertility preservation, resulting in successful pregnancies and live births.headmorphologycancerpopulation
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