Participantsperformintervalwalkingtraining(IWT)aroundtheirhomesandvisitacommunityofficeonceamonthtotransfertheirwalkingrecordtoasevercomputerviaaninternet.Accordingtotheatrendgraphsentbackbythesever,theyareinstructedhowtoperformIWTbytrainersetc.Recently,wehavedevelopedsmartphoneapplicationforthissystem.Measurementsofesophagealtemperature,skinbloodflowandsweatrateduringcyclingexercise.Exercise causes methylation (inactivation) of proinflammatory genes to prevent lifestyle-related diseases.Human embryonic stem cells-derived cardiomyocytes characterized with specific structure and protein expressionUreteric buds induced from a mesonephric duct by growth factorsCSC-like colony reprogrammed from retinoblastoma cancer cells (RBC51)2Sports Medical SciencesHistology & EmbryologyProf. Shizue MasukiResearch subject1) To provide the strategy to prevent heat illness during exercise2) To provide the strategy to prevent lifestyle-related diseases with deterioration3) To provide the epigenetic mechanisms for the effects of exercise trainingOutlook for researchWehavedevelopede-HealthPromotionSystem,composedofIntervalWalkingTraining(IWT),portablecaloriemeter,andITnetworksystem.Byusingthesystem,wehaveaccumulatedthedatabase(DB)ontheeffectsof5-moIWTinseveralthousandmiddle-agedandolderpeople.ByusingtheDB,wewilldevelopaprogramtopredicttheeffectsofIWTtoencouragetheparticipantstocontinueIWTfromtheirphysicalcharacteristicswithgeneticbackground.Thereby,wewilltransformmedicalservicefromtreatmenttoprevention.Outlook for students after graduationResearcherstomajorexerciseandappliedphysiology.Medicalstaffworkingforpreventiveandrehabilitationmedicine.Researchersinprivatecompaniestreatingwithhealthpromotionfoodordevice.Associate Prof.Kohei JohkuraResearch subject?Creating Cancer Stem Cells by Reprogramming TechnologyOutlook for researchThepromisingfieldofregenerativemedicineistorestorestructureandfunctionofdamagedtissuesandorgans.Itisalsopossibletofindwaystocurecancerandgeneticdisorders.Outlook for students after graduationManygraduatesaredoingresearchworksinmedicalfieldsinUniversitiesorprivateinstitutions.Exercise physiology to solve the current social problems !Differentiation, Regeneration and OncogenesisOurgoalistoprovideevidence-basedinformationtosolvethecurrentsocialproblems;globalwarmingandadvancedaging.Humanbeingshavelivedbroadlyontheearthbytheirhighabilitytoadaptthehot/coldenvironmentsbynature.However,theamenitythatincludingfoodandmedicalconditions,hasdeterioratedtheirabilityandthewasteofnaturalresourcestoattaintheamenityhasacceleratedthedepletionoftheresourcestocausetheglobalwarming.Tocuttheviscouscircle,wewouldliketoproposetoreactivatetheirgeneticresourcestoadapttheenvironments.theyacquired,of physical fitness with agingByusingpluripotentstemcellswhichcancreatealmostanycelltype,itispossibletocureinjuriesanddiseasesthatcouldnotbetreatedbefore.Forexample,stemcellsaredifferentiatedintospecializedcellswithuniquefunctionsandtransplantedwhendamagedcellsarenolongerabletohealthemselves.Alternatively,tissuesororgansarecreatedfromstemcellsandtransplantedtoreplacedamagedparts.Wearepromotingstemcellresearchtoelucidatethecausesofintractablediseasesandcontributetotheirtreatment.To study the mechanism of carcinogenesis and develop therapeutic methods by reprogramming cancer cells into cancer stem cells.?DevelopmentandRegenerationofKidneyTo study the mechanisms that support the developmental competence of kidney germ tissues with the use of animal embryos.?Establishment of Disease Model with Patient Specific iPSCellsTo elucidate the pathogenesis of Ehlers-Danlos syndrome, a kind of heterogeneous connective tissue disorder.?Functional Analysis of Epigenetic Factors in Pluripotent Stem CellsTo study why various cells in the body maintain their different state of differentiation, even though they have the same genetic information.2024-2025医学科188bet体育_188bet备用网址紹介
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