?Biological significance of LOX-1 gene family?Screening of LOX-1 blocker to realize a novel therapeutics?Development of novel diagnostic technologies for clinical applicationofHypoglossal nucleus in the rat brain (upper). Nissl-stained (lower left) and tracer-labelled (lower right) hypoglossal motor neurons.Ligament of the ankle joint.(Masson'strichromestaining)Skull suture. Hematoxylin-eosin (left) andMasson's trichrome (right) staining.LOX-1 promotes each stage of arteriosclerotic disease.信州大学医学部医学科発行年月：２０２４年７月発行：信州大学医学部3Prof. NanaeFukushimaResearch subject?Functionally essential neuronal population?Functional regeneration of the nervous system?Estimation of the total number of neurons?Joint structure and function?Skull suturesOutlook for researchBodyfunctionsareimpairedduetovariousfactors.Elucidationofthestructureandfunctionwillleadtoadvancesindiagnosisandtreatmentofdiseaseandinjury.Outlook for students after graduationInourcanacquiretheknowledgeofstudentsneuroanatomyandskillsoftechniquesforhistochemicalstudy.Additionally,theywillacquiretheproblem-solvingabilitythatisusefulaftergraduation.Prof. TatsuyaSawamuraResearch subjectOutlook for students after graduationParticipatingintheresearchactivity,studentscanlearnwhatistocreatemedicalvalue.Theexperiencewouldbebeneficialtocontributetocreateinnovativeproductsformedicaldiagnosisandtherapeutics.AnatomyMolecularPathophysiologyAnatomical study of structure and function“A man is as old as his arteries”For prediction and prevention of atherosclerotic diseaseweareinchargeofthelecturesandpracticaltrainingofneuroanatomyandgrossanatomyformedicalschoolstudents.Anatomyisthestudyofthestructureandfunctionofthehumanbody,buttherearestillmanythingsthathavenotbeenstudied.Weaimtoelucidatethestructureandfunctionofthenervoussystemandjointusingacombinationofmicroandmacroexperiments.laboratory,Our goal is to elucidate the physiological, and pathophysiological mechanisms of vascular function and its disruption through investigating the biology of endothelial cells. Intheprocess,wehavefoundakeymolecule,LOX-1,whichmightillustratethepathophysiologyofatherothromboticdisease.Sincethevascularfunctioniscloselyrelatedtoageing-relatedmalfunctioningoforgans,thefindingopenedanewavenueforunderstandingageing-relateddiseases.Basedontheclues,wearedevelopingnoveldiagnostic,preventiveandtherapeuticmethods.ourresearch?Mechanism of ageing and ageing-related diseasesOutlook for researchThebasicresearchhassignificanceinitself,clarifyingthemechanismofnature.Besides,importantaswellistheapplicationofthenovelknowledgeandtechnologiestothefutureofmedicineandpeople’shappiness.Our study is to contribute to medical diagnosis and therapeutics of lifestyle-related diseases, preventing ageing of vasculature and realizing healthy longevity.
元のページ ../index.html#8