WA20dimerFoldontrimerSelf-assemblyWA20-foldonProtein Nano-building Block(PN-Block)Barrel6-merS form modelTetrahedron12-merM form modelProfessorARAIRyoichiAssociateProfessorAraijoinedShinshuUniversityin2007afterworkingasaresearcheratRIKENandPrincetonUniversityintheU.S.Hisareasofresearcharestructuralbiologytoanalyzethethree-dimensionalstructureandfunctionproteinofengineeringusefulproteinsthroughtheirmodificationanddesign.ProfessorKAJIURAZentaProfessoracademicKajiura'scredentialsareinagriculture,andhisareasofspecializationincludeagricultureandappliedentomology,moleculargenetics.Keywords:DNA,bio-resources,breedingproteins,toanddevelopJA,or40Anexperimentintheresearchlab(upperleft),productionofusefulproteinswithmicroorganisms(upperright),proteincrystalswhichshinelikeapreciousstone(lowerleft),andanX-raydiffractionexperimentatasynchrotronradiationfacility(lowerright)FusionSelf-assemblingnanoarchitecturesarecreatedfromaproteinnano-buildingblockbyfusingadimericdenovoproteinWA20andatrimericfoldondomainfromT4phage.(Kobayashi,N.etal.,J.Am.Chem.Soc.,137,11285-11293,2015)Cocoons and silk from natural silkworms. The cocoons take on a beautiful green color that is unique to Japanese cocoons.Isucceededinbreedingthelargewildsilkworm.Standardwildsilkwormsareshowninthetoprow.Thelargewildsilkwormisshowninthebottomrow.Iusuallyneedmorethan3000cocoonsofthestandardwildsilkwormtoget1kgrawsilk.However,Ionlyneedapproximately2000cocoonsifIusethelargesizewildsilkworm.Outlook for researchOurgoalistoapplyproteinsinvariousfields,forexampleinbiotechnologyandpharmaceuticaldevelopment,inordertodevelopeco-friendlyhighlygreenchemistrycatalysts,high-sensitivitybiosensors,andeffectivevaccines.Intheseways,wehopetocontributetheachievementofasustainablesociety.nanomaterials,functionalOutlook for students after graduationGraduatesareemployedinnumerousfields,includingfood,pharmaceutical,optics,chemical,andbiochemicalcompanies.atOutlook for researchMygoalistotrainnewtalentthatcancarryonthetraditionofcultivatingandproducingnaturalsilk.Thiswillcreateafuture,wheretheproductionofsilkandotheragriculturalproductsisreinvigoratedthroughacollaborationbetweenagriculture,business,andindustry.Outlook for students after graduationGraduatesgoontograduateschoolorworkattextileandfoodcompanies,localcompanies.Someserveasmiddleschoolteachersandpublicofficialsinagriculturalstudies.Iamcarryingoutresearchintogeneticbreeding,ecdysisandmetamorphosis,andthegeneticrelationshipofthesilkwormtoitsrelative,silkworm(naturalsilkworm).MylabcultivatesexcellentstrainsofnaturalsilkwormsinordertoreinvigorateJapan‘ssilkindustry.Thisisdonebysupportingtheraisingofnaturalsilkwormsinsilk-producingregions.Wearecarryingoutresearchtogainadeeperunderstandingofthestructureandfunctionofproteinsandtodesign,develop,andapplyusefulartificialandengineeredproteins.Inthefieldsofproteindesignandengineering,ourlabusescuttingedgetechnologytosee,analyze,create,andapplyusefulproteins.thegiantApplied BiologyApplied BiologyDepartment ofDepartment ofDeveloping the genetic resources of domestic and wild silkworms to make a brand of silkDesigning and developing useful proteins by studying the structure and function of proteins
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