45AssociateProfessorSHIRAIKojiAssociateProfessorShiraitookhiscurrentpositionafterworkingasaCOEspecialtheNationalInstituteofSericulturalandEntomologicalScienceoftheMinistryofAgriculture,Forestry,andFisheriesandasanassistantprofessoratShinshuUniversity.Hisareasofspecializationarebiologicalchemistryandmolecularcellbiologyforutilizinginsectsandinsectcells.AssociateProfessorTAKASHIMASeijiAfterreceivingadoctorate(inengineering)TokyoInstituteTechnology,AssociateProfessorTakashimaworkedasaresearchfellowattheUniversityofTokyobeforecomingKyotoUniversityasanassistantprofessor.Hisareasofresearchareregenerativemedicineandstemcellbiology.researcheratfromofThegreenlarvaofthesweetpotatohornworm,Agriusconvolvuli,alargelepidopteraninsectfoundthroughoutJapan.Adye-bindingproteinextractedfromthedermalcellofaninsect.Theproteincontainscluesaboutproteinsecretioncontrol.GScells.Left:MouseGScellsgrowinginvitro.Center:SpermatogenesisinthetestistransplantedwithGScellsexpressinggreenfluorescentprotein(GFP).Right:MouseoffspringproducedfromspermderivedfromGScellsexpressingGFP.TheoffspringalsoexhibitedgreenfluorescenceunderUVlight.ThepluripotencypotentialofGScells.Left:mGScellsde-differentiated(rejuvenated)fromGScells.mGScellspossesspluripotencylikeiPScells.Right:mGScancontributetotheformationof“chimeramice.”mGS-derivedtissueinthechimaeramiceexhibitedGFPexpression.Outlook for researchThepicturetotherightshowsagreenlarva.Inthislarva,dye-bindingproteinsarestoredingranulesinepidermalcells.Mylabisresearchingthemechanismbywhichthesegranulesareformed.Bydiscoveringhowthatoccurs,wehopeamechanismbywhichsecretoryproteinscanbemaintainedwithincells.toalsodiscoverOutlook for students after graduationGraduates are active as researchers at food and pharmaceutical manufacturers and as public officials.Outlook for researchThespermatogenicpotentialofGScellsisexpectedtofindapplicationnotonlyintreatingmaleinfertility,butalsoinproducingsuperiorlivestock.Inaddition,mGScellsareexpectedtoserveasanothersourceofpluripotentstemcellssuchasiPScells.Inthiscontext,GScellsmightbecalledmultipotentstemcellswiththepotentialtocontributetoawiderangeoffields.Outlook for students after graduationThevalueofthemarketassociatedwithregenerativemedicineisexpectedtogrowto1trillionyenin2020(accordingtostatisticsfromtheMinistryofEconomy,TradeandIndustry).Itismyhopethatourfuturecolleagueswillbeabletoplayaremarkableroleingrowthindustries,includinginregenerativemedicine.Insectsarethemostprosperousanimalsontheearth.Theyemployartfultotheenvironment,andeachspecieshasdevelopeduniqueinvestigateattractiveandusefulcapabilitiesoffeatures.insectsinordertoleveragethemtobenefitourdailylivesinthefuture.Insectsarenotcompletelydifferentfromus,afactthatisclearevenifweonlyconsidertheirmorphology.Researchintothespecialfeaturesofinsectsprovidesuswithimportantcluestounderstandingourselvesashumans.IsurvivalstrategiestoadaptUnderstanding the nature of stem cells and controlling their fateRegenerativemedicineusingiPScellsisexpectedtoserveasanovelapproachforcuringdisease.Mylabisfocusingongermlinestem(GS)cells,tissue-specificstemcellsintestis.AlthoughGScellshavealreadycommittedtogermcelllineage,theyalsohavepluripotencypotentialandoftende-differentiateintomultipotentGS(mGS)cellsthatpossesspluripotencylikeiPScells.ThegoalofourresearchistounderstandtheuniquenatureofGS/mGScellsandcontroltheirfate.Applied BiologyApplied BiologyDepartment ofDepartment ofStudying the capabilities and survival strategies of insects and leveraging them in daily life
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