46Subculture2nd generationSuccessive cultures reduced fruiting body productivity.Subculture3rdgenerationAssociateProfessorNEGISHIJunAfterreceivingadoctorateinTokyoMedicalandDentalUniversity,AssociateprofessorNegishiworkedasaJSPSpostbeforecomingADEKAasaresearchworker.Hisareasofresearcharebiologicalmaterials.AssociateProfessorNOGAWAMasahiroAssociateNogawatookhiscurrentpositionafterworkingasanassistantprofessorattheNagaokaUniversityofTechnology.Hisprincipalareasofresearchappliedmicrobiology.ProfessorarePromotion of neurite outgrowth of decellularized tissues.Fruiting bodies emerged from silkworm pupaeSubculture1st generationCell introduction into a porous material by VPI.Fruiting bodies produced on solid mediumOutlook for researchDecellularizedtissueshavesubstance-specificfunctions,andbybindingtocells,theymaybeabletocreatecomplexbiologicaltissuesandorgansinsideandoutsidethebody.Wealsobelievethatwecandevelopmaterialswithunprecedentedcharacteristicsbymakingfulluseoftechnologiesinvariousfields.Outlook for students after graduationThroughresearch,Iwantyoutolearntothink,act,andworkasateam.Ihopethatyouwillmakeuseofyourexperienceinthelaboratoryandplayanactiveroleinvariousfields.Outlook for researchC.militariscontainsvariousbioactivesubstancessuchascordycepin,whichexhibitsanti-tumoractivity.Fruitingbodyofthefungusisexpectedforapplicationsinhealth-enhancingfoods,supplements,cosmetics,andmore.Outlook for students after graduationWhilemanygraduatesareemployedbyfoodcompanies,othersworkatcomputerandchemicalcompaniesandaspublicofficials,forexampleasplantprotectionofficers.Decellularizedtissueobtainedbyremovingcellsfromlivingtissueconsistsofextracellularmatrix(ECM)andisknowntohavetissue-specificfunctions.Inourlaboratory,wecreateandanalyzedecellularizedtissuefromvarioustissues,clarifythefactorsandcharacteristics,andaimtoapplyittotissueregeneration.Vacuumpressureimpregnationmethod(VPI)usedinmetalprocessingisatechnologythatenablestheefficientintroductionofsolutionsintomaterials.ByapplyingVPItobiomaterialresearch,weaimtodevelopporousmaterialsthatcontaincellsandcompositematerialswithnewproperties.ChinesecaterpillarfungihavebeenprizedasaningredientintraditionalChinesemedicine.Cordycepsmilitarisisdistributedworldwideandproducesorangefruitingbodiesfromthepupaoflepidopterousinsects.Artificialcultivationmethodforthefungushavebeendeveloped,butcontinuousculturefrequentlyresultsinthedegenerationofthefungus.Thismakeslarge-scalecultivationofthefungusdifficult.Mylaboratoryistryingtodevelopastablecultivationreduceddeteriorationofthefruitingbodies.systemforC.militariswithApplied BiologyApplied BiologyDepartment ofDepartment ofBiomaterials that take advantage of the characteristics of biological tissuesArtificial cultivation system for chinesecaterpillar fungus(Cordyceps militaris)
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