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Department of Life Innovation

As the social environment and population structure change dramatically, we are developing infrastructure technology and its social implementation to establish strategies for individual life design towards the ideal way for people to contribute to society. We also aim to elucidate the fundamental principles in the formation of life and disease, especially of human transformation with aging.

  • 1. Cultured vascular endothelial cells forming a mesh structure
  • 2. Abnormal findings in an adrenomedullin knockout mouse

Researchers List

Researcher Directory
Head of the Division of Life Innovation
Academic Assembly Professor (Institute of Medicine)
Ph. D. in Medicine
Research Professor
Takayuki Shindo
Takayuki Shindo
Career
March 1991: Graduated from Faculty of Medicine, The University of Tokyo
June 1991: Department of Internal Medicine, Toranomon Hospital
April 1994: Entered Doctoral Course, Graduate School of Medicine, The University of Tokyo
March 1998: Ph.D. in Medicine, Graduate School of Medicine, The University of Tokyo
July 2002: Assistant Professor, Department of Cardiovascular Medicine, The University of Tokyo
August 2004: Professor, Department of Organogenesis and Regeneration, Shinshu University
April 2012: Professor, Department of Cardiovascular Research, Shinshu University
April 2025: Head, Division of Life Innovation, Institute for Biomedical Sciences, Shinshu University
Research Field
Cardiovascular Research, Developmental engineering
Research Theme
?Therapeutic and diagnostic strategies for lifestyle-related and chronic diseases via AM-RAMP targeting
?Novel vascular homeostasis-based approaches to control cancer metastasis and ocular diseases
?Development of novel genome editing tools and advanced disease model mice
Message
In the Division of Life Innovation, we aim to elucidate the mechanisms of lifestyle-related and aging-associated diseases and to develop innovative therapeutic strategies through the integration of agricultural and medical sciences. By leveraging genome editing, disease model mice, and functional food research, we are committed to accelerating the real-world implementation of Aging Bioscience.
Academic Assembly Professor
(Institute of Medicine)
Ph. D. in Medicine
Research Professor
Naoki Tanaka
Researcher Directory
Research Field
Hepatology/Gastroenterology, Metabolism, Clinical Nutrition
Research Theme
?Diagnosis of metabolic dysfunction-associated fatty liver disease (MASLD) and development of new therapies
?Development of new therapies for liver fibrosis
?Effects of diet on intestinal microbiota and gut/liver
?Development of plant-derived functional foods to prevent obesity-related diseases
Home Page
/faculty/medicine/eng/graduate/course/162090.html
Deputy Director of the Institute for Biomedical Sciences
Academic Assembly Professor (Institute of Agriculture)
Ph. D. in Fisheries Sciences
Research Professor
Shigeru Katayama
Researcher Directory
Research Field
Improvement of bioactive compounds by chemical, enzymatic and genetic modifications
Research Theme
We investigate the health functionality of food-derived bioactive compounds and their improvement by different kinds of modification techniques
Home Page
http://karamatsu.shinshu-u.ac.jp/lab/fs/english.html
Academic Assembly Professor (Institute of Agriculture)
Ph. D. in Agriculture
Research Professor
Takeshi Shimosato
Researcher Directory
Career

Research Field
Molecular Biotechnology
Research Theme
Immunomodulation of oligodeoxynucleotide particles via oral delivery
Academic Assembly Professor (Institute of Textile Science and Technology)
Ph. D. in Engineering
Shimosato Unit
Ryoichi Arai
Researcher Directory
Research Field
Protein engineering, Structural Biology, Synthetic Biology
Research Theme
We conduct protein engineering research to design, develop and apply useful artificial and engineered proteins, and structural biology research to analyze protein structure and function. In particular, we aim for biomolecular innovation by using protein nanobuilding blocks.
Academic Assembly Associate Professor (Institute of Medicine)
Ph. D. in Science
Shindo Unit
Takayuki Sakurai
Researcher Directory
Research Field
Developmental Engineering, Genome Editing, Developmental Biology
Research Theme
Generation of novel disease and multifactorial disease model mice
Generation of novel genome editing technology
Study for mammalian embryo development and generation of embryo manipulation technology
Academic Assembly Senior Assistant Professor (Institute of Medicine)
Ph. D. in Medicine
Tanaka Unit
Takefumi Kimura
Academic Assembly Assistant Professor (Institute of Medicine)
Ph. D. in Medicine
Shindo Unit
Akiko Kamiyoshi
Researcher Directory
Research Field
Metabolism, Endocrinology
Research Theme
Regulation of energy metabolism of adipocytes by bioactive peptide
Mechanisms of liver protection by bioactive peptide
Academic Assembly Assistant Professor
(Institute of Agriculture)
Ph. D. in Agriculture
Katayama Unit
Wataru Nomura
Researcher Directory
Research Field
Applied Molecular Cell Biology
Research Theme
Regulatory mechanisms of signal transduction under conditions of environmental stress in yeast
Regulation of enzymes in the yeast fermentation pathway and its relationship to stress responses
Specially Appointed Assistant Professor (School of Medicine)
Ph. D. in Medicine
Shindo Unit
Megumu Tanaka
Research Field
Onco-cardiology, Vascular biology
Research Theme
Elucidation of the mechanism of suppressing cancer metastasis by maintaining vascular homeostasis
Elucidation of the mechanism of benign cancer-associated fibroblasts by bioactive peptides