丂丂丂丂丂丂

庴徿

丂
崅寣埑娭楢幘姵儌僨儖妛夛丂拞旜徿乮2021乯
Journal of Atherosclerosis and Thrombosis丂擭娫嵟桪廏榑暥乮2019乯
傾僋僥儕僆儞丂傾僇僨儈傾僾儔僀僘乮2017乯
68th AACC Annual Scientific Meeting Lipoproteins and Vascular Diseases Division Abstract Award丂(2016)丂
崙棫弞娐婍昦尋媶僙儞僞乕丂暯惉25擭搙庒庤尋媶彠椼徿丂(2013)
13th International Conference on Endothelin丂ET-13 Travel Grant丂(2013)
戞23夞擔杮弞娐栻棟妛夛丂Young Investigator Award丂(2013)
戞17夞擔杮怱寣娗撪暘斿戙幱妛夛丂庒庤尋媶彠椼徿丂(2013)
戞86夞擔杮惗壔妛夛丂楅栘峢堦儊儌儕傾儖徿丂(2013)
戞8夞媨嶈僒僀僄儞僗僉儍儞僾丂儎儞僌桪廏徿丂(2012)
戞85夞擔杮栻棟妛夛擭夛丂桪廏敪昞徿丂(2012)丂

庡梫榑暥

仠Chen, C.H., Sawamura, T., Akhmedov, A., Tsai, M.H., Akyol, O., Kakino, A., Chiang, H.H., Kraler, S. and Luscher, T.F.: Evolving concepts of low-density lipoprotein: From structure to function. Eur J Clin Invest, 55:e70019, 2025
仠Sasaoka, M., Kakino, A., Villalobos-Labra, R., Yamashita, Y., Spaans, F., Joshita, S., Hosoda, H., Uehara, T., Chen, C.H., Davidge, S.T. and Sawamura, T.: A novel ELISA system for measuring modified LDL-adiponectin complex. J Atheroscler Thromb, 2025.
仠Ihara, J., Huang, Y., Takami, Y., Nozato, Y., Takahashi, T., Kakino, A., Wang, C., Wang, Z., Guo, Y., Liu, W., Yin, N., Ohara, R., Fujimoto, T., Yoshida, S., Hongyo, K., Koriyama, H., Akasaka, H., Takeshita, H., Sakai, S., Inoue, K., Isaka, Y., Rakugi, H., Sawamura, T. and Yamamoto, K.: Oxidized low-density lipoprotein potentiates angiotensin II-induced Gq activation through the AT1-LOX1 receptor complex: Implications for renal dysfunction. eLife, 13:RP98766, 2024.
仠Nguyen, C. T., Nakayama, M., Ishigaki, H., Kitagawa, Y., Kakino, A., Ohno, M., Shingai, M., Suzuki, Y., Sawamura, T., Kida, H. and Ito, Y.: Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection in cynomolgus macaque. Virology, 594:110052, 2024.
仠Takahashi, K., Aono, J., Nakao, Y., Hamaguchi, M., Suehiro, C., Kurata, M., Sakaue, T., Kakino, A., Sawamura, T., Inoue, K., Ikeda, S., Suzuki, J. and Yamaguchi, O.: LOX-1 deficiency increases ruptured abdominal aortic aneurysm via thinning of adventitial collagen. Hypertens Res, 46:63-74, 2023.
仠 Hosomi, K., Kawashima, H., Nakano, A., Kakino, A., Okamatsu-Ogura, Y., Yamashita, Y., Sasaoka, M., Masuda, D., Yamashita, S., Chen, C.H., Yuzuriha, S., Hosoda, H., Iida, H. and Sawamura, T.: NanoSPECT imaging reveals the uptake of 123I-labeled oxidized low-density lipoprotein in the brown adipose tissue of mice via CD36. Cardiovasc Res, , 119:1008-1020, 2023.
仠Sata, M., Kakino, A.(co-first author), Hirata, A., Iida, M., Usami, Y., Harada, S., Fujita, Y., Kohsaka, S., Izawa, Y., Sawano, M., Oki, K., Sugiyama, D., Takahashi, S., Takebayashi, T., Sawamura, T. and Okamura, T.: Serum modified high-density lipoprotein and risk of atherosclerotic cardiovascular disease in a Japanese community-based nested case-control study. Eur J Prev Cardiol, 29:e193-e195, 2022.
仠Ohno, M., Sasaki, M., Orba, Y., Sekiya, T., Masum, M.A., Ichii, O., Sawamura, T., Kakino, A., Suzuki, Y., Kida, H., Sawa, H. and Shingai, M.: Abnormal blood coagulation and kidney damage in aged hamsters infected with severe acute respiratory syndrome coronavirus 2. Viruses, 13:2137, 2021.
仠Ohno, M., Kakino, A., Sekiya, T., Nomura, N., Shingai, M., Sawamura, T. and Kida, H.: Critical role of oxidized LDL receptor-1 in intravascular thrombosis in a severe influenza mouse model. Sci Rep, 11:15675, 2021.
仠Joshita, S., Yamashita, Y., Okamoto, T., Usami, Y., Sugiura, A., Yamazaki, T., Kakino, A., Ota, M., Sawamura, T. and Umemura, T.: Quantitative and qualitative lipid improvement with chronic hepatitis C virus eradication using direct-acting antivirals. Hepatol Res, 51:758-766, 2021.
仠Yokoyama, S., Kawai, T., Yamamoto, K., Yibin, H., Yamamoto, H., Kakino, A., Takeshita, H., Nozato, Y., Fujimoto, T., Hongyo, K., Takahashi, T., Nakagami, F., Akasaka, H., Takami, Y., Takeya, Y., Sugimoto, K., Sawamura, T. and Rakugi, H.: RAGE ligands stimulate angiotensin II type I receptor (AT1) via RAGE/AT1 complex on the cell membrane. Sci Rep, 11:5759, 2021.
仠Takahashi, T., Huang, Y., Yamamoto, K., Hamano, G., Kakino, A., Kang, F., Imaizumi, Y., Takeshita, H., Nozato, Y., Nozato, S., Yokoyama, S., Nagasawa, M., Kawai, T., Takeda, T., Fujimoto, T., Hongyo, K., Nakagami, F., Akasaka, H., Takami, Y., Takeya, Y., Sugimoto, K., Gaisano, H.Y., Sawamura, T. and Rakugi, H.: The endocytosis of oxidized LDL via the activation of the angiotensin II type 1 receptor. iScience, 24:102076, 2021.
仠Kakino, A., Fujita, Y., Ke, L.Y., Chan, H.C., Tsai, M.H., Dai, C.Y., Chen, C.H. and Sawamura, T.: Adiponectin forms a complex with atherogenic LDL and inhibits its downstream effects. J Lipid Res,  62:100001, 2021.
仠Hirata, A., Kakino, A.(co-first author), Okamura, T., Usami, Y., Fujita, Y., Kadota, A., Fujiyoshi, A., Hisamatsu, T., Kondo, K., Segawa, H., Sawamura, T., Miura, K., Ueshima, H. and Group, S.R.: The relationship between serum levels of LOX-1 ligand containing ApoAI as a novel marker of dysfunctional HDL and coronary artery calcification in middle-aged Japanese men. Atherosclerosis, 313:20-25, 2020.
仠Kitano, V.J.F., Ohyama, Y., Hayashida, C., Ito, J., Okayasu, M., Sato, T., Ogasawara, T., Tsujita, M., Kakino, A., Shimada, J., Sawamura, T. and Hakeda, Y.: LDL uptake-dependent phosphatidylethanolamine translocation to the cell surface promotes fusion of osteoclast-like cells. J Cell Sci, 133:jcs243840, 2020.
仠Lee, A.S., Wang, Y.C., Chang, S.S., Lo, P.H., Chang, C.M., Lu, J., Burns, A.R., Chen, C.H., Kakino, A., Sawamura, T. and Chang, K.C.: Detection of a high ratio of soluble to membrane-bound LOX-1 in aspirated coronary thrombi from patients with ST-segment-elevation myocardial infarction. J Am Heart Assoc, 9:e014008, 2020.
仠Kakino, A., Usami, Y., Horiuchi, S., Fujita, Y., Kotani, K., Chen, C.H., Okamura, T. and Sawamura, T.: A novel cell-free, non-fluorescent method to measure LOX-1-binding activity corresponding to the functional activity of HDL. J Atheroscler Thromb, 26:947-958, 2019.
仠Nakano, A., Kawashima, H., Miyake, Y., Zeniya, T., Yamamoto, A., Koshino, K., Temma, T., Fukuda,T., Fujita, Y., Kakino, A., Kanaya, S., Sawamura, T. and Iida, H.: 123I-labeled oxLDL is widely distributed throughout the whole body in mice. Nucl Med Mol Imaging, 52:144-153, 2018.
仠 Kakino, A., Fujita, Y., Nakano, A., Horiuchi, S. and Sawamura, T.: Developmental endothelial locus-1 (Del-1) inhibits oxidized low-density lipoprotein activity by direct binding, and its overexpression attenuates atherogenesis in mice. Circ J, 丂80:2541-2549, 2016
仠 Yokoyama, C., Aoyama, T., Ido, T., Kakino, A., Shiraki, T., Tanaka, T., Nishigaki, K., Hasegawa, A., Fujita, Y., Sawamura, T. and Minatoguchi, S.: Deletion of LOX-1 Protects against Heart Failure Induced by Doxorubicin. PLoS One, 11:e0154994, 2016.
仠 Yokota, C., Sawamura, T., Watanabe, M., Kokubo, Y., Fujita, Y., Kakino, A., Nakai, M., Toyoda, K., Miyamoto, Y. and Minematsu, K.: High Levels of Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Acute Stroke: An Age- and Sex-Matched Cross-Sectional Study. J Atheroscler Thromb, 2016
仠 Yamamoto, K., Kakino, A.(co-first author), Takeshita, H., Hayashi, N., Li, L., Nakano, A., Hanasaki-Yamamoto, H., Fujita, Y., Imaizumi, Y., Toyama-Yokoyama, S., Nakama, C., Kawai, T., Takeda, M., Hongyo, K., Oguro, R., Maekawa, Y., Itoh, N., Takami, Y., Onishi, M., Takeya, Y., Sugimoto, K., Kamide, K., Nakagami, H., Ohishi, M., Kurtz, T.W., Sawamura, T. and Rakugi, H.: Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor. FASEB J, 29:3342-3356, 2015
仠 Nakayachi, M., Ito, J., Hayashida, C., Ohyama, Y., Kakino, A., Okayasu, M., Sato, T., Ogasawara, T., Kaneda, T., Suda, N., Sawamura, T. and Hakeda, Y.: Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state. Bone, 75:170-182, 2015.
仠 Okamura, T., Sekikawa, A., Sawamura, T., Kadowaki, T., Barinas-Mitchell, E., Mackey, R.H., Kadota, A., Evans, R.W., Edmundowicz, D., Higashiyama, A., Nakamura, Y., Abbott, R.D., Miura, K., Fujiyoshi, A., Fujita, Y., Murakami, Y., Miyamatsu, N., Kakino, A., Maegawa, H., Murata, K., Horie, M., Mitsunami, K., Kashiwagi, A., Kuller, L.H., Ueshima, H. and Group, E.J.S.: LOX-1 ligands containing apolipoprotein B and carotid intima-media thickness in middle-aged community-dwelling US Caucasian and Japanese men. Atherosclerosis, 229:240-245, 2013
仠 Ishikawa, M., Ito, H., Akiyoshi, M., Kume, N., Yoshitomi, H., Mitsuoka, H., Tanida, S., Murata, K., Shibuya, H., Kasahara, T., Kakino, A., Fujita, Y., Sawamura, T., Yasuda, T. and Nakamura, T.: Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis. Arthritis Rheum, 64:1024-1034, 2012.
仠 Nishizuka, T., Fujita, Y., Sato, Y., Nakano, A., Kakino, A., Ohshima, S., Kanda, T., Yoshimoto, R. and Sawamura, T.: Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox. Proc Jpn Acad Ser B Phys Biol Sci, 87:104-113, 2011.
仠 Iwamoto, S., Fujita, Y., Kakino, A., Yanagida, K., Matsuda, H., Yoshimoto, R. and Sawamura, T.: An alternative protein standard to measure activity of LOX-1 ligand containing apoB (LAB) - utilization of anti-LOX-1 single- chain antibody fused to apoB fragment. J Atheroscler Thromb, 18:818-828, 2011.
仠 Fujita, Y., Yamaguchi, S., Kakino, A., Iwamoto, S., Yoshimoto, R. and Sawamura, T.: Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation. Clin Chem, 57:1398-1405, 2011.
仠 Nakano, A., Inoue, N., Sato, Y., Nishimichi, N., Takikawa, K., Fujita., Kakino, A., Otsui, K., Yamaguchi, S., Matsuda, H. and Sawamura, T.: LOX-1 mediates vascular lipid retention under hypertensive state. J Hypertens, 28:1273-1280, 2010.
仠 Matsumoto, T., Fujita, M., Sawamura, T., Kakino, A., Sato, Y., Fujita, Y., Matsuda, H., Nakanishi, M., Uchida, K., Nakae, I., Kanda, H., Yoshida, A., Miwa, K., Hayashi, H., Mitsunami, K. and Horie, M.: Pitavastatin reduces lectin-like oxidized low-density lipoprotein receptor-1 ligands in hypercholesterolemic humans. Lipids, 45:329-335, 2010.
仠 Inoue, N., Okamura, T., Kokubo, Y., Fujita, Y., Sato, Y., Nakanishi, M., Yanagida, K., Kakino, A., Iwamoto, S., Watanabe, M., Ogura, S., Otsui, K., Matsuda, H., Uchida, K., Yoshimoto, R. and Sawamura, T.: LOX index, a novel predictive biochemical marker for coronary heart disease and stroke. Clin Chem, 56:550-558, 2010.
仠 Fujita, Y., Kakino, A., Harada-Shiba, M., Sato, Y., Otsui, K., Yoshimoto, R. and Sawamura, T.: C-reactive protein uptake by macrophage cell line via class-A scavenger receptor. Clin Chem, 56:478-481, 2010.
仠 Sugimoto, K., Ishibashi, T., Sawamura, T., Inoue, N., Kamioka, M., Uekita, H., Ohkawara, H., Sakamoto, T., Sakamoto, N., Okamoto, Y., Takuwa, Y., Kakino, A., Fujita, Y., Tanaka, T., Teramoto, T., Maruyama, Y. and Takeishi, Y.: LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells. Cardiovasc Res, 84:127-136, 2009.
仠 Fujita, Y., Kakino, A., Nishimichi, N., Yamaguchi, S., Sato, Y., Machida, S., Cominacini, L., Delneste, Y., Matsuda, H. and Sawamura, T.: Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects. Clin Chem, 55:285-294, 2009.
仠 Ikura, T., Tashiro, S., Kakino, A., Shima, H., Jacob, N., Amunugama, R., Yoder, K., Izumi, S., Kuraoka, I., Tanaka, K., Kimura, H., Ikura, M., Nishikubo, S., Ito, T., Muto, A., Miyagawa, K., Takeda, S., Fishel, R., Igarashi, K. and Kamiya, K.: DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics. Mol Cell Biol, 27:7028-7040, 2007.

強懏妛夛

擔杮惗壔妛妛夛
擔杮栻棟妛夛
擔杮摦柆峝壔妛夛