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過去５年間（原著論文?総説?著書）
【2016年】
?Taniguchi S, Shimatani Y, Fujimori M
Tumor-targeting therapy using gene-engineered anaerobic-nonpathogenic Bifidobacterium longum.
Methods Mol Biol. 1409:49-60, 2016
【2015年】
?Shirasuna K, Karasawa T, Usui F, Kobayashi M, Komada T, Kimura A, Ohkuchi A, Taniguchi S, Takahashi M.
NLRP3 deficiency improves angiotensin II-induced hypertension but not fetal growth restriction during pregnancy.
Endocrinology 156(11):4281-4292, 2015
?Shirasuna1 K, Usui F , Karasawa T, Kimura H, Kawashima A, Hiroaki Mizukami H, Ohkuchi A,
Nishimura S, Sagara J, Noda T, Ozawa K, Taniguchi S, Takahashi M.
Nanosilica-induced placental inflammation and pregnancy complications: Different roles of the inflammasome components NLRP3 and ASC.
Nanotoxicology.9(5):554-567, 2015
?Kadoya H, Satoh M, Sasaki T, Taniguchi S, Takahashi M, Kashihara N
Excess aldosterone is a critical danger signal for inflammasome activation in the development of renal fibrosis in mice.
The FASEB Journal 29:3899-3910, 2015
?Zhang Y, Hashimoto S, Fujii C, Hida S, Ito K, Matsumura T, Sakaizawa T, Morikawa M, Masuki S, Nose H, Higuchi K, Nakajima K, Taniguchi S
NFκB2 gene as a novel candidate that epigenetically responds to interval walking training
Int J Sports Med. 36(9):769-775, Aug. 2015
?Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, Karasawa T, Yoshimura K, Aoki H,
Tsutsui H, Noda T, Sagara J, Taniguchi S, Takahashi M.
Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the
development of angiotensin Ⅱ-induced aortic aneurysm.
Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):127-136.
【2014年】
?Itoh A, Uchiyama A, Taniguchi S, Sagara J,
Phactr3/scapinin, a member of protein phosphatase 1 and actin regulator (phactr) family, interacts with the plasma membrane via basic and hydrophobic residues in the N-terminus
PLoS One. 9(11):e113289, Nov 2014
?Shirasuna1 K, Usui F , Karasawa T, Kimura H, Kawashima A, Hiroaki Mizukami H,
Ohkuchi A, Nishimura S, Sagara J, Noda T, Ozawa K, Taniguchi S, Takahashi M
Nanosilica-induced placental inflammation and pregnancy complications: Different roles of
the inflammasome components NLRP3 and ASC
Nanotoxicology. 11:1-14, Sep 2014
?Pawared Ontong, Hatada Y, Taniguchi S, Kakizaki I, Itano N.
Effect of a cholesterol-rich lipid environment on the enzymatic activity of reconstituted
hyaluronan synthase.
Biochem. & Biophysical Research Communications.443:666-671, 2014
?Komada T, Usui F, Shirasuna K, Kawashima A, Kimura H, Karasawa T, Nishimura S, Sagara J, Noda T, Taniguchi S, Muto S, Nagata D, Kusano E, Takahashi M
ASC in Renal Collecting Duct Epithelial Cells Contributes to Inflammation and Injury after
Unilateral Ureteral Obstruction.
Am J Pathol 184(5):1287-1298, May 2014
?Inoue Y, Shirasuna K, Kimura H, Usui F, Kawashima A, Karasawa T, Tago K, Dezaki,
Nishimura S, Sagara J, Noda T, IwakuraY, Hiroko Tsutsui H, Taniguchi S, Yanagisawa K, Yada T, Yasuda Y, Takahashi M.
NLRP3 Regulates Neutrophil Functions and Contributes to Hepatic Ischemia-Reperfusion
Injury Independently of Inflammasomes.
J Immunol. 192(9):4342-4351, May 2014
?Imanishi T, Ishihara C, Badr Mel S, Hashimoto-Tane A, Kimura Y, Kawai T, Takeuchi O,
Ishii KJ, Taniguchi S, Noda T, Hirano H, Brombacher F, Barber GN, Akira S, Saito T
Nucleic acid sensing by T cells initiates Th2 cell differentiation.
Nat Commun. 10;5:3566. Apr 2014
?谷口俊一郎
ビフィズス菌を利用した固形がん治療の試み
Japanese Journal of Lactic Acid Bacteria 25(1):18-23, 2014
?谷口俊一郎
ビフィズス菌を用いた抗がん剤開発
BIO INDUSTRY 31(5):43-48, 2014
【2013年】
?Negishi H, Matsuki K, Endo N, Sarashina H, Miki S, Matsuda A, Fukazawa K,
Taguchi-Atarashi N, Ikushima H, Yanai H, Nishio J, Honda K, Fujioka Y, Ohba Y, Noda T,
Taniguchi S, Nishida E, Zhang Y, Chi H, Flavell RA, Taniguchi T.
Beneficial innate signaling interference for antibacterial responses by a Toll-like receptor-
mediated enhancement of the MKP-IRF3 axis.
Proc Natl Acad Sci U S A, 110(49):19884-19889, Dec. 2013
?Shimane T, Kobayashi H, Takeoka M, Kitazawa M, Matsumura T, Hida S, Tiepeng Xiao,
Koike T, Taniguchi S, Kurita H.
Clinical significance of apotosis-associated speck-like protein containing a caspase
recruitment domain in oral squamous cell carcinoma.
Oral & Maxillofacial Pathology 115(6):799-809,2013
?Ikuta T, Kobayashi Y, Kitazawa M, Shiizaki K, Itano N, Noda T, Pettersson S,
Poellinger L, Fujii-Kuriyama Y, Taniguchi S, Kawajiri K.
ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon
receptor- deficient mice.
Carcinogenesis. 2013 Mar 1. [Epub ahead of print]
?Kashima Y, Takahashi M, Shiba Y, Itano N, Izawa A, Koyama J, Nakayama J,
Taniguchi S, Kimata K, Ikeda U.
Crucial Role of Hyaluronan in Neointimal Formation after Vascular Injury.
PLOS ONE. 2013 Mar:8(3) :e58760
【2012年】
?谷口俊一郎
１０代からの「いのち学」 ーあるがん188bet体育_188bet备用网址者のつぶやきー
オフィスエム 2012.9.9
?Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, Karasawa T, Hida S, Sagara J,
Taniguchi S, Takahashi M.
Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in
Western diet-fed apolipoprotein E-deficient mice.
Biochem Biophys Res Commun. 425:162-168, 2012 Jul 20.
? Imamura T, Ishizuka O, Lei Z, Hida S, Sudha GS, Kato H, Nishizawa O.
Bone marrow-derived cells implanted into radiation-injured urinary bladders
reconstruct functional bladder tissues in rats.
Tissue Eng Part A. 2012 Aug;18(15-16):1698-709. doi:
10.1089/ten.TEA.2012.0061. Epub 2012 May 14.
? Notake T, Horisawa S, Sanjo H, Miyagawa S, Hida S, Taki S.
Differential requirements for IRF-2 in generation of CD1d-independent T cells bearing NK cell receptors.
J Immunol. 2012 May 15;188(10):4838-45. Epub 2012 Apr 13.
【2011年】
?Yoshizawa, K., Nakajima, S., Notake, S., Miyagawa, S., Hida, S., Taki, S.
IL-15-high-responder developing NK cells bearing Ly49 receptors in IL-15-/- mice.
J. Immunol. 187: 5162-5169. 2011
?Hata T, Takahashi M, Hida S, Kawaguchi M, Kashima Y, Usui F, Morimoto H,Nishiyama A,
Izawa A, Koyama J, Iwakura Y, Taki S, Ikeda U.
Critical role of Th17 cells in inflammation and neovascularization after ischaemia.
Cardiovasc Res. 90 (2): 362-372, 2011
?Yamazaki H, Takeoka M, Kitazawa M, Ehara T, Itano N, Kato H, Taniguchi S.
ASC plays a role in the priming phase of the immune response to type II collagen in collagen-induced arthritis.
Rheumatol Int. 2011 Feb 18. [Epub ahead of print]
?Nishimura Y, Biborka Bereczky, Yoshioka K, Taniguchi S, Itoh K
A novel role of Rho-kinase in the regulation of ligand-induced phosphorylated EGFR
endocytosis via the early/late endocytic pathway in human fibrosarcoma cells.
J Mol Histol. 2011 Aug 17. [Epub ahead of print]
? Kawaguchi M, Takahashi M, Hata T, Kashima Y, Usui F, Izawa A, Takahashi Y, Masumoto J,
Koyama J, Hongo M, Noda T, Nakayama J, Sagara J, Taniguchi S, Ikeda U.
Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial
Ischemia/Reperfusion Injury.
Circulation. 123:594-604, 2011
? 谷口俊一郎
嫌気性菌をがんへの”運び屋”にする
科学 0219 , 2011
【2010年】
?Kobayashi N, Miyoshi S, Mikami T, Koyama H, Kitazawa M, Takeoka M, Sano K,
Amano J, Isogai Z, Niida S, Oguri K, Okayama M, John A. McDonald, Kimata K, Taniguchi
S, Itano N.
Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor
Neovascularization.
Cancer Res. 70(18): 7073-7083, 2010
? Taniguchi S, Fujimori M, Sasaki T, Tsutsui H, Shimatani Y, Seki K, Amano J.
Targeting solid tumors with non-pathogenic obligate anaerobic bacteria.
Cancer Sci. 101(9):1925-1932, 2010
? Yanagisawa S, Takeichi N, Kaneyama T, Yagita H, Taniguchi S, Byung S.Kim,
Chang-Sung Koh
Effects of Anti-CD70 mAb on Theiler’s Murine Encephalomyelitis Virus-Induced
Demyelinaiting Disease.
Brain Res. 2010 Mar 4;1317:236-45. Epub 2010
? Nakajima K, Takeoka M, Mori M, Hashimoto S, Sakurai A, Nose H, Higuchi K,
Itano N,Shiohara M, Oh T, Taniguchi S.
Exercise Effects on Methylation of ASC Gene.
Int. J. Sports Med. 31:671-675, 2010
? Sugaya A, Takeoka M, Itano N, Taguchi A, Ehara T, Taniguchi S.
Calponin h1-S175T Point Mutation Enhances Resistance to
Actin Cytoskeleton Perturbation in Human Cancer Cells
Anticancer Research 30:1071-1078, 2010
? Imamura R, Wang Y, Kinoshita T, Suzuki M, Noda T, Sagara J, Taniguchi S,
Okamoto H, Suda T.
Anti-inflammatory activity of PYNOD and its mechanism in humans and mice.
J. Immunol.184(10):5874-84, 2010
? Toma C, Higa N, Koizumi Y, Nakasone N, Ogura Y, McCoy AJ, Franchi L,
Uematsu S, Sagara J, Taniguchi S, Tsutsui H, Akira S, Tschopp J, Nú?ez G,
Suzuki T.
Pathogenic Vibrio activated NLRP3 inflammasome via cytotoxins and TLR/NOD-
Mediated NF-κB signaling.
J. Immunol.184(9):5287-97, 2010
? Yotsumoto N, Takeoka M, Yokoyama M.
Tail-Suspended Mice Lacking Calponin H1 Experience Decreased Bone Loss.
Tohoku J. Exp. Med.211:221-227, 2010
?Seto T, Kamijyo S, Wada Y, Yamaura K, Takahashi K, Komatsu K, Otsu Y, Terasaki T,
Fukui D, Amano J, Taniguchi S, Sagara J, Ito K
Upregulation of the apoptosis-related inflammasome in cardiac allograft rejection.
J Heart and Lung Transplantation. 29(3):352-359, 2010
? 谷口俊一郎：
「ビフィズス菌を用いた固形がんの治療」ー 低酸素環境を標的とする選択的デリバリー ー
化学と生物 Vol.48 No.10, p671-673, 2010
? 肥田重明、瀧伸介:「好塩基球からのIL-4産生誘導機序」
炎症と免疫, Vol.18 No.1, p9-13, 2010
? 肥田重明、瀧伸介:「Th2分化と好塩基球」
実験医学（増刊）28(12):71-76, 2010
?肥田重明、瀧信介
好塩基球を介した免疫応答制御
臨床免疫?アレルギー科54(3):352-360, 2010
★1995-2009年業績