Achievements
2024
? Usuda Y, Okihara T, Moriyama S, Uemura T, Kamanaka T,Omi AM, Saito N,Takahashi J, Aoki K, Nishimura N.Development of phosphate-treated PEEK implants with high osseointegration. Materials Today Communications 38, 107717, 20242023
? Tanaka Y, Kadota S, Zhao J, Kobayashi H, Okano S, Izumi M, Honda Y, Ichimura H, Shiba N, Uemura T, Wada Y,Chuma S, Nakada T, Tohyama S, Fukuda K, Yamada M, Seto T, Koichiro K, Shiba Y. Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Promote Angiogenesis through Alpha-B Crystallin. Stem Cell Research ＆ Therapy 14, 240, 2023? Cheung A, Konno K, Imamura Kawasawa Y, Pochareddy S, Matsui A, Abe M, Sakimura K, Sasaoka T, Uemura T, Watanabe M, Futai K*. Neurexins in serotonergic neurons regulate serotonin transmission and complex mouse behaviors. eLife 12, e85058, 2023
? Ueda K, Ma C,Izumiya M, Kuroda C, Ishida H, Uemura T, Saito N, Aoki K*, Haniu H*. Biocompatibility Evaluation of Carbon Nanohorns in Bone Tissues. Nanomaterials 13, 244, 2023
2022
? Saito N, Haniu H, Aoki K, Nishimura N, Uemura T. Future Prospects for Clinical Applications of Nanocarbons Focusing on Carbon Nanotubes. Advanced Science, e2201214, 2022? Uemura T*, Suzuki-Kouyama E, Kawase S, Kurihara T, Yasumura M, Yoshida T, Fukai S, Yamazaki M, Fei P, Abe M, Watanabe M, Sakimura K, Mishina M, Tabuchi K*. Neurexins Play a Crucial Role in Cerebellar Granule Cell Survival by Organizing Autocrine Machinery for Neurotrophins. Cell Reports 39, 110624, 2022
? Kim D, Jung H, Shirai Y, Kim J, Kim H, Mori T, Lee H, Park D, Kim HY, Guo Q, Pang B, Qiu W, Cao X, Kouyama-Suzuki E, Uemura T, Kasem E, Fu Y, Kim S, Tokunaga A, Yoshizawa T, Suzuki T, Sakagami H, Lee KJ, Ko J, Tabuchi K*, Um JW*. IQSEC3 deletion impairs fear memory through upregulation of ribosomal S6 kinase 1 signaling in the hippocampus. Biological Psychiatry 91, 821–831, 2022
2021
? Ideta H, Yoshida K, Okamoto M*, Sasaki J, Kito M, Aoki K, Yoshimura Y, Suzuki S, Tanaka A, Takazawa A, Haniu H, Uemura T, Takizawa T, Sobajima A, Kamanaka T, Takahashi J, Kato H, Saito N. Antitumor effect of sclerostin against osteosarcoma. Cancers 13, 6015, 2021? Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Nakashima S, Shiroshima T, Maeda A, Iwasawa-Okamoto S, Azechi K, Osaka F, Saitoh T, Maenaka K, Shimada T, Fukata Y, Fukata M, Matsumoto J, Nishijo H, Takao K, Tanaka S, Okabe S, Tabuchi K, Uemura T, Mishina M, Mori H, Fukai S. Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice. Nature Communications 12, 1848, 2021.
? Hisano K, Yoshida H, Kawase S, Mimura T, Haniu H, Tsukahara T, Kurihara T, Matsuda Y, Saito N, Uemura T. Abundant oleoyl-lysophosphatidylethanolamine in brain stimulates neurite outgrowth and protects against glutamate toxicity in cultured cortical neurons. [published online ahead of print April 5, 2021]. The Journal of Biochemistry. DOI: 10.1093/jb/mvab046.
? Izumiya M, Haniu M, Ueda K, Ishida H, Ma C, Ideta H, Sobajima A, Ueshiba K, Uemura T, Saito N, Haniu H. Evaluation of MC3T3-E1 cell osteogenesis in different cell culture media. International Journal of Molecular Sciences 22, 7752, 2021.
? Hisano K, Kawase S, Mimura T, Yoshida H, Yamada H, Haniu H, Tsukahara T, Kurihara T, Matsuda Y, Saito N, Uemura T. Structurally different lysophosphatidylethanolamine species stimulate neurite outgrowth in cultured cortical neurons via distinct G-protein-coupled receptors and signaling cascades. Biochemical and Biophysical Research Communications. 534, 179–185, 2021.
2020
? Kamanaka T, Haniu H, Tanaka M, Takizawa T, Aoki K, Okamoto M, Sobajima A, Yoshida K, Ideta H, Mimura T, Ishida H, Ueda K, Uemura T, Kim J, Kim YA, Kato H, Saito N. Carbon fibers for treatment of cancer metastasis in bone. RSC Advances 10, 33071, 2020? Uchigashima M, Konno K, Demchak E, Cheung A, Watanabe T, Keener D.G, Abe M, Le T, Sakimura K,Sasaoka T, Uemura T, Imamura Kawasawa Y, Watanabe M, Futai K*. Specific Neuroligin3-αNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus. eLife 9, e59545, 2020.
? Tsukahara T, Haniu H, Uemura T, Matsuda Y. Therapeutic potential of porcine liver decomposition product: New insights and perspectives for microglia-mediated neuroinflammation in neurodegenerative diseases. Biomedicines 8, 446, 2020.
? Matsuda Y, Haniu H, Tsukahara R, Uemura T, Inoue T, Sako K, Kojima J, Mori T, Ueki A, Sato K. Oral administration of porcine liver decomposition product for 4 weeks enhances visual memory and delayed recall in healthy adults over 40 years of age: A randomized, double-blind, placebo-controlled study. Experimental Gerontology,141, 111064, 2020.
? Sano M, Izumiya M, Haniu H, Ueda K, Konishi K, Ishida H, Kuroda C, Uemura T, Aoki K, Matsuda Y, Saito N. Cellular Responses of Human Lymphatic Endothelial Cells to Carbon Nanomaterials. Nanomaterials 10, 1374, 2020.
? Tsukahara T, Haniu H, Uemura T, Matsuda Y. Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro. Scientific Reports 10, 3748, 2020
? Kurihara T, Kouyama-Suzuki E, Satoga M, Li X, Badawi M, Thiha, Baig DN, Yanagawa T, Uemura T, Mori T, Tabuchi K. DNA repair protein RAD51 enhances the CRISPR/Cas9-mediated knock-in efficiency in brain neurons. Biochemical and Biophysical Research Communications 524, 621–628, 2020
? Yoshida K, Okamoto M, Sasaki J, Kuroda C, Ishida H, Ueda K, Ideta H, Kamanaka T, Sobajima A, Takizawa T, Tanaka M, Aoki K, Uemura T, Kato H, Haniu H, Saito N*. Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells. BMC Cancer 20, 25, 2020
2019
? Mori T, Kasem EA, Suzuki-Kouyama E, Cao X, Kurihara T, Uemura T, Yanagawa T, Tabuchi K. Deficiency of calcium/calmodulin-dependent serine protein kinase (CASK) disrupts the excitatory-inhibitory balance of synapses by down-regulating GluN2B. Molecular Psychiatry 24, 1079–1092, 2019? Yoshida K, Okamoto M, Sasaki J, Kuroda C, Ishida H, Ueda K, Okano S, Ideta H, Kamanaka T, Sobajima A, Takizawa T, Kito M, Aoki K, Uemura T, Haniu H, Kato H, Saito N. Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T cell activation markers. OncoTargets and Therapy 12, 2513-2518, 2019
2018
? Yamagata A, Goto-Ito S, Sato Y, Shiroshima T, Maeda A, Watanabe M, Saitoh T, Maenaka K, Terada T, Yoshida T, Uemura T*, Fukai S*. Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction. Nat. Commun. 9, 3964, 2018 (* corresponding author)? Kawabata GK, Fujishima K, Mizuno H, Lee SJ, Uemura T, Sakimura K, Mishina M, Watanabe N, Kengaku M. MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells. Cell Rep. 24, e9, 2018
? Goto-Ito S, Yamagata A, Sato Y, Uemura T, Shiroshima T, Maeda A, Imai A, Mori H, Yoshida T, Fukai S. Structural basis of trans-synaptic interactions between PTPδ and SALMs for inducing synapse formation. Nat. Commun. 9, 269, 2018
2017
? Uemura T*, Shiroshima T, Maeda A, Yasumura M, Shimada T, Fukata Y, Fukata M, Yoshida T*. In situ screening for postsynaptic cell adhesion molecules during synapse formation. Journal of Biochemistry 162, 295-302, 2017 (* corresponding author)2016
? Uemura T*, Mori T, Kurihara T, Kawase S, Koike R, Satoga M, Cao X, Li X, Yanagawa T, Sakurai T, Shindo T, Tabuchi K*. Fluorescent protein tagging of endogenous protein in brain neurons using CRISPR/Cas9-mediated knock-in and in utero electroporation techniques. Scientific Reports 6 ,35861, 2016 (* corresponding author)2015
? Yamagata A, Sato Y, Goto-Ito S, Uemura T, Maeda A, Shiroshima T, Yoshida T, Fukai S. Structure of Slitrk2-PTPδ complex reveals mechanisms for splicing-dependent trans-synaptic adhesion. Scientific Reports 5, 9686, 2015? Yamagata A, Yoshida T, Sato Y, Goto-Ito S, Uemura T, Maeda A, Shiroshima T, Iwasawa-Okamoto S, Mori H, Mishina M, Fukai S. Mechanisms of splicing-dependent trans-synaptic adhesion by PTPδ-IL1RAPL1/IL-1RAcP for synaptic differentiation. Nature Communications 6, 6926,2015
2014
? Yasumura M, Yoshida T, Yamazaki M, Abe M, Natsume R, Kanno K, Uemura T, Takao K, Sakimura K, Kikusui T, Miyakawa T, Mishina M. IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours. Scientific Reports 4, 6613, 2014.? Ikegami M, Uemura T, Kishioka A, Sakimura K, Mishina M*. Striatal dopamine D1 receptor is essential for contextual fear conditioning. Scientific Reports 4, 3976, 2014
? Hirano K, Kinoshita T, Uemura T, Motohashi H, Watanabe Y, Ebihara T, Nishiyama H, Sato M, Suga M, Maruyama Y, Tsuji NM, Yamamoto M, Nishihara S, Sato C*. Electron microscopy of primary cell cultures in solution and correlative optical microscopy using ASEM. Ultramicroscopy 143, 52–66, 2014
2013
? Mishina M, Yoshida T, Yasumura M, Uemura T, Synapse formation in the brain. Cortical Development. Neural Diversity and Neocortical Organization In : Kageyama R and Yamamori T (eds), Cortical Development , Chapter 11, Springer Japan, Tokyo Japan, pp229－247, 2013? Kishioka A, Uemura T, Fukushima F, Mishina M. Consolidation of auditory fear memories formed by weak unconditioned stimuli requires NMDA receptor activation and de novo protein synthesis in the striatum. Molecular Brain 6, 17, 2013
2012
? Mishina M, Uemura T, Yasumura M, Yoshida T. Molecular mechanism of parallel fiber-Purkinje cell synapse formation. Front. Neural. Circuits 6, 90, 2012? Yoshida T, Shiroshima T, Lee SJ, Yasumura M, Uemura T, Chen X, Iwakura Y, Mishina M. Interleukin-1 Receptor Accessory Protein organizes neuronal synaptogenesis as a cell adhesion molecule. Journal of Neuroscience 32, 2588－2600, 2012
? Yasumura M, Yoshida T, Lee SJ, Uemura T, Joo JY, Mishina M. Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with neurexins through cerebellin precursor protein subtypes. Journal of Neurochemistry 12, 705－716, 2012
? Lee SJ, Uemura T, Yoshida T, Mishina M. GluRδ2 Assembles Four Neurexins into Trans-Synaptic Triad to Trigger Synapse Formation. Journal of Neuroscience 32, 4688－4701, 2012
2011
? Yoshida T, Yasumura M, Uemura T, Lee SJ, Ra M, Taguchi R, Iwakura Y, Mishina M. IL-1 Receptor Accessory Protein-Like 1 Associated with Mental Retardation and Autism Mediates Synapse Formation by Trans-Synaptic Interaction with Protein Tyrosine Phosphatase δ. Journal of Neuroscience 31, 13485－13499, 2011? #Joo JY, #Lee SJ, #Uemura T, Yoshida T, Yasumura M, Watanabe M, Mishina M. Differential Interactions of Cerebellin Precursor Protein (Cbln) Subtypes and Neurexin Variants for Synapse Formation of Cortical Neurons. Biochemical and Biophysical Research Communications 406, 627－632, 2011 # equally contribution
2010
? Uemura T, Lee SJ, Yasumura M, Takeuchi T, Yoshida T, Ra M, Taguchi R, Sakimura K, Mishina M. Trans-synaptic interaction of GluRδ2 and neurexin through Cbln1 mediates synapse formation in the cerebellum. Cell 141, 1068－1079, 20102008
? Uemura T, Mishina M. The amino-terminal domain of glutamate receptor δ2 triggers presynaptic differentiation. Biochemical and Biophysical Research Communications 377, 1315－1319 , 2008? #Yasumura M, #Uemura T, Yamasaki M, Sakimura K, Watanabe M, Mishina M. Role of the internal Shank-binding segment of glutamate receptor δ2 in synaptic localization and cerebellar functions. Neuroscience Letters 433, 146－151, 2008 # equally contribution
2007
? Uemura T, Kakizawa S, Yamasaki M, Sakimura K, Watanabe M, Iino M, Mishina M. Regulation of long-term depression and climbing fiber territory by glutamate receptor δ2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells. Journal of Neuroscience 27, 12096－12108, 20072004
? Uemura T, Mori H, Mishina M. Direct interaction of GluRδ2 with Shank scaffold proteins in cerebellar Purkinje cells. Molecular and Cellular Neuroscience 26, 330－341, 20042003
? Mizuta R, Iwai K, Shigeno M, Mizuta M, Uemura T, Ushiki, T, Kitamura D. Molecular visualization of immunoglobulin switch region RNA/DNA complex by atomic force microscope. Journal of Biological Chemistry 278, 4431－4434, 20032002
? Uemura T, Mori H, Mishina M. Isolation and Characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain. Biochemical and Biophysical Research Communications 296, 492－496, 2002