LOX-1偲嵶朎愙拝

LOX-1偺妶惈壔偼丄寣娗撪旂嵶朎偱嵶朎愙拝暘巕偺敪尰槾恑傪堷偒婲偙偟丄偙傟偵傛傝敀寣媴偺寣娗撪旂嵶朎傊偺愙拝傪懀恑偟偰偄傞偲峫偊傜傟傞偑丄LOX-1偦偺傕偺偑庬乆偺嵶朎偲捈愙憡屳嶌梡偡傞偙偲傕柧傜偐偵側偭偰偄傞丅

榁壔愒寣媴丒傾億僩乕僔僗嵶朎

巁壔LDL偼丄偁傞堄枴偱惗懱撪偺榁攑暔偱偁傞偲峫偊傜傟傞偺偱丄LOX-1偺傛偆側巁壔LDL庴梕懱偑丄傗偼傝惗懱偺榁攑暔偲傕偄偊傞巰嵶朎丒榁壔嵶朎偺擣幆偵娭傢傞偺偱偼側偄偐偲偄偆壜擻惈傪峫偊偨偙偲偐傜丄偙偺尋媶偼巒傑偭偰偄傞丅摉帪丄巰嵶朎婷怘偺尋媶偼帀幙偲偼慡偔撈棫偟偨椞堟偺壢妛偱偁偭偨偑丄傾億僩乕僔僗偺弶婜抜奒偱僼僅僗僼傽僠僕儖僙儕儞偑乮PS乯偑嵶朎枌昞柺偵業弌偡傞偙偲偑尒弌偝傟乮Martin, S.J. et al. J Exp Med 1995乯丄帀幙尋媶偲偺愙揰偑惗傑傟偨丅

捠忢丄嵶朎枌儕儞帀幙擇廳憌偼丄奜懁偺憌偲撪懁偺憌偼懳徧偱偼側偔丄奜懁偺憌偱偼儕儞帀幙偼拞惈儕儞帀幙偺僼僅僗僼傽僠僕儖僐儕儞乮PC乯偑傎偲傫偳偱丄巁惈儕儞帀幙偺PS傗僼僅僗僼傽僠僕儖僄僞僲乕儖傾儈儞乮PE乯偼撪懁偵曃嵼偟偰偄傞丅偙偺儕儞帀幙偺嵶朎枌擇廳憌偱偺旕懳徧惈偼ATP埶懚惈僼儕僢僷乕僛偺摥偒偵傛偭偰堐帩偝傟偰偄傞丅偟偐偟丄傾億僩乕僔僗偺弶婜抜奒偱偼丄偙偺旕懳徧惈偑曵夡偟偰PS偑嵶朎奜偵業弌偡傞丅旕懳徧惈偺曵夡偵偼Ca2+埶懚惈偺僗僋儔儞僽儔乕僛偲偄偆峺慺偑娭梌偡傞偲峫偊傜傟偰偄傞丅

偱偼丄LOX-1偼巰嵶朎丄榁壔嵶朎傪擣幆丒婷怘偡傞偺偱偁傠偆偐丠LOX-1傪夘偟偨嵶朎愙拝傗嵶朎婷怘嶌梡傪挷傋傞偨傔丄撪旂嵶朎傗LOX-1敪尰嵶朎偵丄榁壔儌僨儖愒寣媴丄傑偨偼僔僋儘僿僉僔儈僪偱傾億僩乕僔僗傪桿摫偟偨HL-60嵶朎傪揧壛偡傞偲丄撪旂嵶朎偍傛傃LOX-1敪尰嵶朎偼丄榁壔愒寣媴傗傾億僩乕僔僗嵶朎偲寢崌偟偰婷怘偟偨丅堦曽丄LOX-1傪敪尰偟側偄嵶朎偱偼丄偙偺傛偆側嵶朎愙拝丒嵶朎婷怘偼娤嶡偝傟側偐偭偨丅偙偺傛偆側愙拝丒婷怘偼傾億僩乕僔僗桿摫偺庬椶傗嵶朎偵傛傜偢丄峈Fas峈懱偱傾億僩乕僔僗偝偣偨Jarkat嵶朎丄TNF-兛偱傾億僩乕僔僗偝偣偨撪旂嵶朎傕摨條偵愙拝偟偨乮Oka, K. et al. Proc Natl Acad Sci USA 1998乯丅

偦偟偰丄LOX-1敪尰嵶朎偼枹張抲偺愒寣媴傗HL-60嵶朎偲偼寢崌偟側偐偭偨偙偲偐傜丄LOX-1偼榁壔傗傾億僩乕僔僗偵敽偭偰婲偙傞嵶朎昞柺偺曄壔傪擣幆偟偰偄傞偲峫偊傜傟偨丅偦偙偱丄儕儞帀幙偲LOX-1偺娭學傪夝愅偟偨丅LOX-1敪尰嵶朎偲榁壔愒寣媴丒傾億僩乕僔僗嵶朎偺寢崌偼丄PS儕億僜乕儉偵傛偭偰慾奞偝傟傞偑丄PC儕億僜乕儉傗PE儕億僜乕儉偺塭嬁傪庴偗側偄偙偲偐傜丄LOX-1偼嵶朎奜偵業弌偟偨PS傪擣幆偟偰偄傞偙偲偑帵嵈偝傟偨丅傑偨丄偙偙偱梡偄偨榁壔儌僨儖愒寣媴偱偼丄榁壔張抲偵偟偨偑偭偰PS偺嵶朎昞柺傊偺業弌偲丄LOX-1偺寢崌惈偺憹壛偑暲峴偟偰婲偒偰偄偨丅

偝傜偵丄LOX-1偲儕儞帀幙偺捈愙偺寢崌幚尡偐傜丄LOX-1偼PC傗PE偲偼寢崌偟側偄偑丄PS偲Ca2+埶懚揑偵捈愙寢崌偡傞偙偲偑柧傜偐偵側偭偨乮Murphy, J.E. et al. Biochem J 2006乯丅偙傟傜偺偙偲偐傜丄LOX-1偼嵶朎枌儕儞帀幙偺拞偱傕PS偲摿堎揑偵寢崌偡傞偙偲偱丄榁壔嵶朎傗傾億僩乕僔僗嵶朎偺慖戰揑側婷怘偵娭梌偟偰偄傞偲峫偊傜傟傞丅

妶惈壔寣彫斅

PS偺嵶朎奜傊偺業弌偼丄嵶朎偺榁壔傗傾億僩乕僔僗偩偗偱偼側偔丄寣彫斅偺妶惈壔偱傕惗偠傞丅偙偺PS偼丄寣塼嬅屌場巕偺曗場巕偲偟偰寣塼偺嬅屌傪懀恑偡傞丅巹払偼丄LOX-1偑PS業弌嵶朎偲寢崌偡傞偙偲偐傜丄撪旂嵶朎偲妶惈壔寣彫斅偑愙拝偟丄寣愷宍惉側偳偵娭學偟偰偄傞偺偱偼側偄偐偲峫偊偰専摙傪峴偭偨丅

ADP偱巋寖偟偨寣彫斅傪丄攟梴撪旂嵶朎偵揧壛偡傞偲丄寣彫斅偼撪旂嵶朎偲愙拝偟偨屻丄婷怘偝傟傞憸偑娤嶡偝傟偨丅摨條偺嵶朎愙拝丒婷怘偼LOX-1敪尰嵶朎偱傕娤嶡偝傟偨偑丄LOX-1傪敪尰偟側偄嵶朎偼寣彫斅偲寢崌偟側偐偭偨乮Kakutani, M. et al. Proc Natl Acad Sci USA 2000乯丅

寣彫斅偲LOX-1敪尰嵶朎偺寢崌偼丄巁壔LDL傗LOX-1峈懱偺揧壛偵傛偭偰慾奞偝傟偨偑丄枹曄惈LDL偺塭嬁傪庴偗側偐偭偨丅寣彫斅偺愙拝偼傑偨丄PS寢崌僞儞僷僋幙傾僱僉僔儞V傗PS儕億僜乕儉偺揧壛偵傛偭偰傕梷惂偝傟偨偑丄PC儕億僜乕儉偺塭嬁偼庴偗側偐偭偨丅埲忋偺寢壥偐傜丄寣彫斅偺愙拝偵偍偄偰LOX-1偲PS偑寢崌偟偰偄傞偙偲偑柧傜偐偵側偭偨丅傑偨丄僩儘儞價儞傗僐儔乕僎儞偱寣彫斅傪妶惈壔偝偣傞偲丄偦偺揧壛検偵墳偠偰LOX-1敪尰嵶朎傊偺寢崌偑槾恑偡傞偙偲偐傜丄寣彫斅妶惈壔偵敽偆PS偺業弌傪LOX-1偼擣幆偟偰偄傞偲峫偊傜傟偨丅 

傑偨丄妶惈壔寣彫斅傪撪旂嵶朎偵愙拝偝偣傞偲丄撪旂偐傜偺僄儞僪僙儕儞-1乮ET-1乯偺暘斿偑LOX-1埶懚揑偵槾恑偟偨丅偙傟偼偦偺傎偐偺幚尡寢壥偐傜丄寣彫斅傛傝曻弌偝傟偨妶惈暔幙偵傛傞傕偺偱偼側偔丄嵶朎偺愙拝帺懱偵傛偭偰堷偒婲偙偝傟傞偲峫偊傜傟偨丅偡側傢偪丄LOX-1傪夘偟偨嵶朎愙拝偦偺傕偺偑嵶朎傊偺巋寖偵側偭偰偄傞偲峫偊傜傟偨丅

LOX-1偲敀寣媴偺憡屳嶌梡偐傜墛徢傊 

師偵LOX-1偺墛徢偵偍偗傞栶妱傪丄僄儞僪僩僉僔儞偱偁傞儕億億儕僒僢僇儔僀僪乮LPS乯傪儔僢僩偵搳梌偡傞儌僨儖偱専摙偟偨丅LPS傪掅擹搙乮0.5 mg/kg乯偱搳梌偡傞僽僪僂枌墛儌僨儖偱偼丄栐枌嵶惷柆偺撪旂嵶朎偵偍偗傞LOX-1偺敪尰偼丄LPS搳梌12帪娫屻偱挊柧偵槾恑偟偰偄偨丅娽朳悈拞傊偺敀寣媴偺怹弫偲僞儞僷僋幙偺楻弌偼LPS搳梌24帪娫屻偵嵟戝偲側偭偨偑丄LPS偲摨帪偵峈LOX-1峈懱傪張抲偡傞偙偲偱丄偙傟傜偼梷惂偝傟偨丅

傑偨丄敀寣媴偺棳検偑嵟戝偵側傞LPS搳梌20帪娫屻偵丄栐枌寣娗偵偍偗傞敀寣媴偺儘乕儕儞僌偲愙拝傪應掕偟偨丅敀寣媴偼撪旂偲憡屳嶌梡偡傞偙偲偱儘乕儕儞僌傪巒傔丄嵟廔揑偵偼撪旂偵愙拝偡傞偑丄LPS偲摨帪偵峈LOX-1峈懱傪搳梌偡傞偲丄敀寣媴偺儘乕儕儞僌偺懍搙偑懍偔側傝丄儘乕儕儞僌偟偰偄傞嵶朎悢傕尭彮偟偨乮Honjo, M. et al. Proc Natl Acad Sci USA 2003乯丅

LOX-1偑敀寣媴傪愙拝偡傞偐偳偆偐挷傋傞偨傔丄僸僩岲拞媴傪梡偄丄in vitro偺棳傟忦審壓偱愙拝幚尡傪峴偭偨丅岲拞媴偼LOX-1傪屌憡壔偟偨僗儔僀僪偵偼愙拝偟偨偑丄IgG傪屌憡壔偟偨僗儔僀僪偵偼寢崌偟側偐偭偨丅峈LOX-1峈懱偺揧壛偵傛偭偰岲拞媴偺愙拝悢偑尭彮偡傞偙偲偐傜丄LOX-1偑岲拞媴偲捈愙寢崌偡傞偙偲偑柧傜偐偵側偭偨丅偙傟傜偺寢壥偼丄僽僪僂枌墛儌僨儖偱娤嶡偝傟偨LOX-1埶懚揑側敀寣媴偺儘乕儕儞僌丒愙拝丒怹弫傪斀塮偟偰偄傞偲峫偊傜傟傞丅

堦曽丄攕寣徢傪崅擹搙LPS乮2 mg/kg乯搳梌偵傛傝桿摫偟偨儔僢僩偼丄1帪娫埲撪偵敀寣媴悢偺尭彮傪婲偙偟丄24帪娫埲撪偵70%偑巰偵帄偭偨丅偟偐偟丄峈LOX-1峈懱傪LPS偲摨帪搳梌偡傞偲丄敀寣媴偺尭彮偼梷惂偝傟丄慡偰偺屄懱偑惗懚偟偨丅尰嵼丄攕寣徢傗SIRS乮Systemic Inflammatory response syndrome乯偺帯椕偵偼僾儘僥僀儞C偺搳梌偑偁傞偑丄偦偺岠壥偼昁偢偟傕廩暘偲偼偄偊側偄丅LOX-1偺慾奞偼丄攕寣徢傗SIRS偵懳偟偰偺怴偟偄岠壥揑側帯椕朄偲側傞壜擻惈偑偁傞丅

 

娭愡墛

娭愡儕僂儅僠乮RA乯偼墛徢惈嵶朎偺怹弫傪敽偆枬惈娭愡墛偱偁傞丅娭愡儕僂儅僠偲摦柆峝壔偺娭學偼屆偔偐傜抦傜傟偰偍傝丄塽妛揑偵傕丄娭愡儕僂儅僠姵幰偱姤摦柆幘姵偺敪徢棪偑忋徃偡傞偙偲偑曬崘偝傟偰偄傞丅傑偨丄娭愡儕僂儅僠姵幰偺妸枌傗娭愡塼拞偵巁壔LDL偑専弌偝傟傞偙偲偐傜丄娭愡墛偵偍偗傞LOX-1偺栶妱偵偮偄偰専摙傪峴偭偨丅

傑偢丄婲墛暔幙偱偁傞僓僀儌僓儞傪儔僢僩旼娭愡偵拲幩偟偰娭愡墛傪桿敪偟偨丅LOX-1偺敪尰偼桿摫6帪娫屻偐傜惷柆偍傛傃暯妸嬝偱娤嶡偝傟丄24帪娫屻偵偼傎傏慡偰偺惷柆偍傛傃嵶惷柆偱敪尰偑擣傔傜傟偨丅LOX-1偺敪尰偼妸枌偍傛傃擃崪偱傕娤嶡偝傟偨偑丄摦柆偱偼擣傔傜傟側偐偭偨丅傑偨丄擃崪偵偍偗傞巁壔LDL偺拁愊偼桿摫6帪娫屻偐傜擣傔傜傟丄72帪娫屻偵帄傞傑偱憹壛傪帵偟偨丅

娭愡旍戝偼桿摫3帪娫屻偐傜擣傔傜傟丄24帪娫屻偵偼娭愡宎偑嵟戝偲側偭偨偑丄峈LOX-1峈懱張抲偵傛傝丄桿摫24帪娫屻偺娭愡旍戝偼嵟戝34%梷惂偝傟丄娭愡峯傊偺敀寣媴偺怹弫傕尭彮偟偰偄偨丅傑偨丄桿摫7擔屻偺擃崪攋夡丄妸枌偺旍岤傕梷惂偝傟偰偍傝丄LOX-1偺慾奞偑媫惈婜偍傛傃垷媫惈婜偺墛徢傪梷惂偡傞偙偲偑柧傜偐偵側偭偨乮Nakagawa, T. et al. Arthritis Rheum 2002乯丅

偦偺屻丄巁壔LDL偲娭愡擃崪偺LOX-1偺寢崌偑NF-內B偺妶惈壔傗妶惈巁慺庬偺嶻惗丄儅僩儕僋僗儊僞儘僾儘僥傾乕僛3乮MMP-3乯偺敪尰傪桿摫偡傞偙偲丄娭愡擃崪偵怢揥僗僩儗僗傪晧壸偡傞偲LOX-1偺敪尰偑憹壛偟丄巁壔LDL埶懚揑側嵶朎巰偑懀恑偝傟傞偙偲偑傢偐偭偨乮Nishimura, S. et al. Osteoarthritis Cartilage 2004; Kakinuma, T. et al. Arthritis Rheum 2004; Akagi, M. et al. J Orthop Res 2006乯丅

偝傜偵僸僩偵偍偄偰丄曄宍惈娭愡徢乮OA乯姵幰偺擃崪偱LOX-1偺敪尰偍傛傃巁壔LDL偺拁愊偑憹壛偟偰偍傝丄椉幰偼嫟嬊嵼偟偰偄傞偙偲偑柧傜偐偵側偭偨丅LOX-1傗巁壔LDL偑梲惈偺嵶朎悢偼丄娭愡墛偺恑揥搙傪昞偡Mankin僗僐傾偲惓偺憡娭傪帵偟偨乮Akagi, M. et al. Osteoarthritis Cartilage 2007乯丅偙偺傛偆側偙偲偐傜丄僸僩偺娭愡墛偱傕LOX-1偲巁壔LDL偑昦懺偺恑峴偵娭傢偭偰偍傝丄LOX-1偑帯椕昗揑偵側傝摼傞壜擻惈偑峫偊傜傟傞丅

 

嶲峫暥專 

Oka, K., Sawamura, T., Kikuta, K., Itokawa, S., Kume, N., Kita, T. and Masaki, T.: Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells. Proc Natl Acad Sci USA, 95:9535-9540, 1998.

Martin, J.S. et al.: Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Ab1. J Exp Med, 182:1545-1556, 1995.

Murphy, J.E., Tacon, D., Tedbury, P.R., Hadden, J.M., Knowling, S., Sawamura, T., Peckham, M., Phillips, S.E.V., Walker, J.H. and Ponnambalam, S.: LOX-1 scavenger receptor mediates calcium-dependent recognition of phosphatidylserine and apoptotic cells. Biochem J, 393;107-115, 2006.

Kakutani, M., Masaki, T. and Sawamura, T.: A platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1. Proc Natl Acad Sci USA, 97:360-364, 2000.

Honjo, M., Nakamura, K., Yamashiro, K., Kiryu, J., Tanihara, H., McEvoy, L. M., Honda, Y., Butcher, E. C., Masaki, T. and Sawamura, T.: Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation. Proc Natl Acad Scie USA, 100:1274-1279, 2003.

Nakagawa, T., Akagi, M., Hoshikawa, H., Chen, M., Yasuda, T., Mukai, S., Ohsawa, K., Masaki, T., Nakamura, T. and Sawamura, T.: Lectin-like oxidized low-density lipoprotein receptor 1 mediates leukocyte infiltration and articular cartilage destruction in rat zymosan-induced arthritis. Arthritis Rheum, 46:2486-2494, 2002.

Nishimura, S., Akagi, M., Yoshida, K., Hayakawa, S., Sawamura, T., Munakata, H. and Hamanishi, C.: Oxidized low-density lipoprotein (ox-LDL) binding to lectin-like ox-LDL receptor-1 (LOX-1) in cultured bovine articular chondrocytes increases production of intracellular reactive oxygen species (ROS) resulting in activation of NF-kappaB. Osteoarthritis Cartilage, 12:568-576, 2004.

Kakinuma, T., Yasuda, T., Nakagawa, T., Hiramitsu, T., Akiyoshi, M., Akagi, M., Sawamura, T. and Nakamura, T.: Lectin-like oxidized low-density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low-density lipoprotein in rheumatoid arthritis cartilage. Arthritis Rheum, 50:3495-3503, 2004.

Akagi, M., Nishimura, S., Yoshida, K., Kakinuma, T., Sawamura, T., Munakata, H. and Hamanishi, C.: Cyclic tensile strech load and oxidized low density lipoprotein synergistically induce lectin-like oxidized LDL receptor-1 in cultured bovine chondrocytes, resulting in decreased cell viability and proteoglycan synthesis. J Orthop Res, 24:1782-1790, 2006.

Akagi, M., Kanata, S., Mori, S., Itabe, H., Sawamura, T. and Hamanishi, C.: Possible involvement of the oxidized low-density lipoprotein/lectin-like oxidized low-density lipoprotein receptor-1 system in pathogenesis and progression of human osteoarthritis. Osteoarthritis Cartilage, 15:281-290, 2006.

尋媶奣梫
巁壔LDL庴梕懱LOX-1偺敪尒
LOX-1偲CRP
LOX-1偵寢崌偡傞撪場惈偺儕億抈敀幙
LOX-1僽儘僢僇乕偺奐敪
LOX-1傪梡偄偨恌抐媄弍偺奐敪