嫹怱徢傗怱嬝峓嵡丄擼寣娗忈奞側偳偺摦柆峝壔惈幘姵偺敪徢儕僗僋昡壙朄偍傛傃敪徢恌抐朄偺妋棫偼丄偙傟傜偺幘姵偺帯椕偲摨偠偔傜偄廳梫側壽戣偱偁傞丅偦偙偱丄巹払偼乮巁壔乯曄惈LDL傗LOX-1偦偺傕偺偺應掕傪偙傟傜偺昡壙丒恌抐朄偵墳梡偡傞偙偲傪峫偊偰偄傞丅

僶僀僆儅乕僇乕偲偟偰偺乮巁壔乯曄惈LDL偲丄偦偺應掕朄 

LDL偼丄扴憲僞儞僷僋幙偱偁傞傾億儕億抈敀B乮apolipoprotein B丗 apoB乯偲丄僐儗僗僥儘乕儖丄僐儗僗僥儘乕儖僄僗僥儖丄僩儕僌儕僙儕僪丄儕儞帀幙側偳偺帀幙惉暘偐傜側傞暘巕検栺2000kDa偺媴忬棻巕偱偁傞丅LDL偼巁壔揑斀墳偵傛傝丄巁壔僼僅僗僼傽僠僕儖僐儕儞丄傾僋儘儗僀儞丄4-僸僪儘僉僔僲僱僫乕儖丄儅儘儞僕傾儖僨僸僪側偳偺帀幙夁巁壔暔傪惗偠丄偙傟傜偺帀幙夁巁壔暔偼丄偝傜偵apoB偺儕僕儞巆婎偺傾儈僲婎偲斀墳偟丄廋忺偡傞丅偟偨偑偭偰丄巁壔LDL偲偼丄條乆側巁壔帀幙丄晹暘揑偵巁壔傪庴偗偨抈敀幙偐傜惉傞晄嬒堦側廤崌懱偱偁傞丅

1990擭戙屻敿偐傜丄傾儖僨僸僪偵傛傝廋忺傪庴偗偨apoB僞儞僷僋幙偺棫懱峔憿傪擣幆偡傞儌僲僋儘乕僫儖峈懱乮Holovet傜偵傛傞乯傗丄巁壔LDL偵娷傑傟傞巁壔僼僅僗僼傽僠僕儖僐儕儞傪擣幆偡傞儌僲僋儘乕僫儖峈懱乮Witztum傜丄斅晹傜偵傛傞乯偑嶌惉偝傟偨丅偙傟傜偺峈懱偲峈apoB峈懱偲慻傒崌傢偣偨僒儞僪僀僢僠ELISA偵傛傝寣拞巁壔LDL抣偺應掕偑峴傢傟丄僸僩寣拞偵妋偐偵巁壔曄惈傪庴偗偨LDL偑懚嵼偡傞偙偲偑帵偝傟偰偄傞丅

偟偐偟丄峈巁壔LDL峈懱傪梡偄偨應掕朄偵偼丄2偮偺栤戣偑偁偭偨丅偡側傢偪丄乮1乯峈懱偱偼丄晄嬒堦側棻巕偱偁傞巁壔LDL偺摿掕偺僄僺僩乕僾偺検偟偐應掕偱偒側偄偙偲丄乮2乯應掕昗弨昳偺巁壔LDL偑丄嶌惢偡傞儘僢僩娫偁傞偄偼嶌惢屻偺帪娫偵傛傝惈幙偑曄傢傞偨傔昗弨昳偲偟偰晄廩暘偱偁傞偙偲偱偁傞丅

應掕朄偺奐敪 

乮1乯峈巁壔LDL峈懱傪梡偄傞偲巁壔LDL偺摿掕偺峔憿偟偐擣幆偟偊側偄偲偄偆栤戣偵懳偟偰丄巹払偼峈懱偺戙傢傝偵LOX-1抈敀傪梡偄丄庴梕懱偵寢崌偡傞妶惈傪掕検偡傞偙偲偵傛傝丄乮巁壔乯曄惈LDL検偺巜昗偲偡傞偙偲傪峫埬偟偨乮Kakutani, M. et al. BBRC 2001乯丅

側偤側傜丄庬乆偺曄惈LDL偼庴梕懱偵條乆側嫮偝乮potency乯偱寢崌偟丄惗暔妛揑側斀墳傪嵶朎偵堷偒婲偙偡偑丄偙偺嵺寢崌偑庛偄傕偺偼懡検偵偁偭偰傕庛偄斀墳傪堷偒婲偙偟丄寢崌偑嫮偄傕偺偼彮検偱嫮偄斀墳傪堷偒婲偙偡偲峫偊傜傟傞偨傔偱偁傞丅偮傑傝丄偳傟偐摿掕偺乮巁壔乯曄惈LDL偺検傪應掕偡傞傛傝偼丄慡懱傪偦偺寢崌偺嫮偝偵墳偠偰乮妶惈乯應掕偡傞曽偑棟偵偐側偭偰偄傞偺偱偼側偄偐偲偄偆偙偲偱偁傞丅

嬶懱揑偵偼丄LOX-1偺儕僈儞僪寢崌椞堟偱偁傞嵶朎奜椞堟偺慻姺偊僞儞僷僋幙傪僾儗乕僩偵屌憡壔偟丄偦偙偵寣燋丒寣惔惉暘拞偺LOX-1儕僈儞僪傪寢崌偝偣丄寢崌偟偨儕億僞儞僷僋幙傪峈apoB峈懱偱専弌偡傞sandwich enzyme immunoassay乮EIA乯偵傛傝應掕偡傞丅偙偺宯傪梡偄偰in vitro偱嶌惢偟偨巁壔LDL偲枹曄惈LDL傪僒儞僾儖偲偟偰梡偄偨偲偙傠丄巁壔LDL偺傒偑専弌偝傟丄偦偺巁壔偺掱搙偵墳偠堎側傞嫮偝偱斀墳偡傞偙偲偑傢偐偭偨丅

乮2乯堦曽丄應掕昗弨昳偺巁壔LDL偺儘僢僩娫偺僶儔偮偒偺栤戣傪夝寛偡傞偨傔偵丄巁壔LDL偺晄埨掕偝偺梫場偵側偭偰偄傞帀幙傪娷傑側偄昗弨昳傪恖岺揑偵嶌惢偡傞偙偲傪峫埬偟偨乮Iwamoto, S. et al. JAT 2011乯丅

應掕昗弨昳偲側傞偨傔偺梫審偼丄LOX-1偲峈apoB峈懱偺椉曽偵摿堎揑偵寢崌偡傞偙偲偱偁傞偺偱丄偙傟傪恖岺揑側慻姺抈敀偵傛傝幚尰偡傞偙偲偵偟偨丅偡側傢偪丄嘆LOX-1傊偺寢崌傪妋曐偡傞偨傔偵峈LOX-1峈懱抐曅傪梡偄丄嘇峈apoB峈懱傊偺寢崌傪妋曐偡傞偨傔偵apoB偺晹暘儁僾僠僪傪梡偄傞偙偲偲偟丄偙傟傜偺梈崌抈敀幙傪敪尰偡傞梈崌cDNA儀僋僞乕傪嶌惢偟偨丅偙傟傪嵶朎偵摫擖偡傞偙偲偵傛傝丄梈崌抈敀傪挷惍偟偨丅偙偺梈崌抈敀幙偼丄幚嵺偵LOX-1偲峈apoB峈懱偵摨帪偵擣幆偝傟丄乮巁壔乯曄惈LDL應掕偺儕僼傽儗儞僗偲偟偰棙梡偱偒偨丅偦偟偰丄婜懸捠傝昗弨昳偲偟偰偺挷惍昳娫偺僶儔偮偒傗晄埨掕惈偼巁壔LDL傛傝傕奿抜偵梷偊傞偙偲偑壜擻偲側偭偨丅

埲壓丄巹払偺曽朄偵傛傝應掕偟偨丄LOX-1偵寢崌偡傞apoB娷桳儕億抈敀乮LOX-1 ligand containg apoB: LAB乯傪乽LOX-1儕僈儞僪乿偲婰弎偡傞丅側偤側傜丄LOX-1傊偺寢崌擻傪摼傞偨傔偺LDL偺惈幙偺曄壔偑巁壔偵傛傞傕偺偩偗側偺偐丄懠偺條幃偺廋忺偑偳傟偔傜偄娭傢偭偰偄傞偺偐丄傑偨LDL偱偼側偄偑丄摨偠偔apoB傪娷桳偡傞怘塧惈偺儕億抈敀丄僇僀儘儈僋儘儞丒儗儉僫儞僩偵偮偄偰偼偳偺傛偆側暘夋偑LOX-1傊偺寢崌偵娭傢偭偰偄傞偺偐丄側偳傑偩尋媶搑忋偱偁傞偨傔偱偁傞丅

摦暔儌僨儖偱偺専徹

忋婰偺LOX-1儕僈儞僪應掕朄傪棙梡偟丄LOX-1儕僈儞僪偺寣拞儗儀儖偲摦柆峝壔偺恑揥偵偮偄偰丄傑偢摦暔儌僨儖偱偺昡壙傪峴偭偨丅傑偢丄崅帀寣徢僂僒僊乮WHHL僂僒僊乯偱偼惓忢僂僒僊乮JW僂僒僊乯偲斾妑偟偰LOX-1儕僈儞僪偑桳堄偵忋徃偟偰偍傝乮Kakutani, M. et al. BBRC 2001乯丄峈巁壔擻偺偁傞價僞儈儞E傗丄HMG-CoA娨尦峺慺慾奞栻乮僗僞僠儞乯偺偆偪峈巁壔擻傪傕偮僼儔僶僗僞僠儞傪搳梌偡傞偲丄寣拞乮巁壔乯曄惈LDL偑掅壓偡傞偲偲傕偵丄摦柆峝壔恑揥偑梷惂偝傟傞偙偲偑柧傜偐偲側偭偨乮Oka, K. et al. J Cardiovasc Pharmacol 2006乯丅

偝傜偵丄儅僂僗儌僨儖偵偍偄偰専摙傪峴偄丄崅帀朾怘傪晧壸偡傞偲丄LOX-1偵寢崌偡傞寣拞偺LOX-1儕僈儞僪偺抣偼戝偒偔憹壛偟丄崅帀寣徢儅僂僗偲偟偰抦傜傟傞apoE寚懝儅僂僗偱偼丄惓忢儅僂僗偵斾偟偰摿偵偦偺曄壔偑尠挊偵尒傜傟偨乮Sato, Y. et al. Atherosclerosis 2008乯丅偦偟偰apoE寚懝儅僂僗偱丄LOX-1儕僈儞僪傪摿堎揑偵庢傝彍偔偨傔丄傾僨僲僂僀儖僗儀僋僞乕偵傛傝娞憻偵LOX-1傪堎強惈敪尰偝偣傞偲丄寣拞偺LOX-1儕僈儞僪擹搙偑掅壓偟丄偦傟偵敽偭偰摦柆峝壔偺恑揥偑梷惂偝傟傞偙偲偑柧傜偐偲側偭偨乮Ishigaki, Y. et al. Circulation 2008乯丅

偡側傢偪丄寣拞偺崅偄LOX-1儕僈儞僪擹搙偼丄寣拞偺崅擹搙偺LDL僐儗僗僥儘乕儖傗摦柆峝壔偺扨側傞寢壥偲偟偰忋徃偟偨偲偄偆偙偲偵偲偳傑傜偢丄偦傟帺懱偑尨場偲側偭偰摦柆峝壔傪恑揥偝偣傞偙偲偑丄彮側偔偲傕摦暔儌僨儖偱偼帵嵈偝傟偨丅

僸僩偱偺専徹亅摦柆峝壔惈幘姵偺敪徢儕僗僋昡壙偵栶棫偮偐丠 

偦偙偱丄僸僩偱傕巹払偑奐敪偟偨LOX-1儕僈儞僪寣拞擹搙應掕偵堄媊偑偁傞偐偳偆偐傪専徹偟偨丅

悂揷尋媶偼崙棫弞娐婍昦尋媶僙儞僞乕偑搒巗晹堦斒巗柉偵偍偗傞怱寣娗昦偺摦懺傪挷嵏偡傞偨傔偵20擭梋傝宲懕偟偰峴偭偰偄傞僐儂乕僩尋媶偱偁傞丅偙偺尋媶傪棙梡偟偰丄暯惉6擭偵悂揷廧柉寬恌傪庴恌偟偨2437柤偱慜岦偒尋媶傪峴偭偨丅暯嬒11擭娫偺擼懖拞丄怱嬝峓嵡偺敪徢傪挷嵏偟偨偲偙傠丄姤摦柆幘姵68柤丄擼懖拞91柤乮偆偪擼峓嵡60柤乯偺敪徢偑娤嶡偝傟偨丅

忋弎偺曽朄偵傛傝LOX-1儕僈儞僪擹搙傪丄LOX-1偵寢崌偡傞apoB娷桳儕億抈敀幙偲偟偰應掕偡傞偲摨帪偵丄壜梟宆LOX-1乮sLOX-1乯偺應掕傕峴偭偨丅側偤側傜丄壜梟宆LOX-1偺検偼LOX-1偺敪尰検傪斀塮偟偰偄傞偲峫偊傜傟傞偨傔丄LOX-1偺儕僈儞僪偲壜梟宆LOX-1偺検傪摨帪偵應掕偡傞偙偲偱丄寣娗偱幚嵺偵婲偒傞LOX-1儕僈儞僪偲LOX-1偺憡屳嶌梡傪悇掕偱偒傞偲峫偊傜傟偨偐傜偱偁傞丅偙偺LOX-1偲儕僈儞僪偺憡屳嶌梡傪斀塮偡傞偲峫偊傜傟傞僷儔儊乕僞乕傪亀LOX Index = 乮LOX-1儕僈儞僪亊sLOX-1乯亁偲偟偰嶼弌偟丄LOX-1儕僈儞僪丄sLOX-1丄LOX Index偺3偮偺僷儔儊乕僞乕偺怱寣娗昦僶僀僆儅乕僇乕偲偟偰偺桳梡惈傪専摙偟偨乮Inoue, N. et al. Clin Chem 2010乯丅偦傟偧傟偺應掕抣偵傛傝丄巐暘埵偵暘偗丄戞1巐暘埵傪婎弨偵偟偰斾椺僴僓乕僪儌僨儖傪棙梡偟偰憡懳婋尟搙傪媮傔傞偲丄LOX-1儕僈儞僪偺戞4巐暘埵偺憡懳婋尟搙偼擼懖拞乮2.09乯丄擼峓嵡乮3.11乯丄姤摦柆幘姵乮1.82乯偄偢傟偵偍偄偰傕嵟傕崅偔丄擼懖拞丒擼峓嵡偵偍偄偰偼桳堄側忋徃偲側偭偨丅sLOX-1偵偍偄偰偼桳堄側曄壔偼擣傔傜傟側偐偭偨乮1.03乣2.13乯丅峏偵LOX Index偱昡壙偟偨応崌丄擼峓嵡偺憡懳婋尟搙偼戞2乣4巐暘埵偺偄偢傟傕戞1巐暘埵偲斾傋偰旕忢偵崅偐偭偨乮3.39, 3.15, 3.23乯丅傑偨丄姤摦柆幘姵偺憡懳婋尟搙傕LOX Index偺戞4巐暘埵偱偼2.09偲桳堄偵忋徃偟偰偄偨丅

偙偺傛偆偵丄LOX-1儕僈儞僪傗LOX Index崅抣偼擼峓嵡敪徢偺旕忢偵嫮偄婋尟場巕偱偁傞偙偲偑柧傜偐偲側偭偨丅擼懖拞偺婋尟場巕偲偟偰偼丄崅寣埑偑傛偔抦傜傟偰偄傞偑丄崅寣埑偵傛傞儕僗僋忋徃偺栺3攞偲摨摍偱偁傞偙偲偐傜丄LOX-1儕僈儞僪傗LOX Index崅抣偼崅寣埑偵旵揋偡傞婋尟場巕偱偁傞偲傕偄偊傞丅傑偨僐儗僗僥儘乕儖抣偼丄彮側偔偲傕偙偺僐儂乕僩偱偼擼懖拞偺婋尟場巕偲偟偰偼擣傔傜傟偢丄擼懖拞偵偮偄偰偼LOX-1儕僈儞僪傗LOX Index崅抣偑僐儗僗僥儘乕儖傛傝傕戝偒側應掕堄媊偑偁傞偙偲傪帵偟偰偄傞丅

巁壔LDL偺尋媶偼挿偄楌巎偑偁傝丄巹払偺應掕崁栚傕巁壔LDL偲娭楢偟偨巜昗偱偁傞偑丄偙傟傑偱偵丄巁壔LDL偵偮偄偰偺寬忢幰偺慜岦偒尋媶偑峴傢傟偨偙偲偼傎偲傫偳側偄丅傢偢偐偵Holvoet傜偑丄寣拞巁壔LDL抣偑崅偄偲儊僞儃儕僢僋僔儞僪儘乕儉偵側傞儕僗僋偑崅偄偙偲傪曬崘偟偰偄傞偺傒偱偁傞乮Holvoet, P. et al. JAMA 2008乯丅偟偨偑偭偰丄幘姵偺敪徢儕僗僋偵偮偄偰崱夞偺傛偆側専摙偑偝傟偨偙偲偼側偔丄巹払偑弶傔偰丄摦柆峝壔惈幘姵偵偮偄偰敪徢儕僗僋偺専徹傪峴偄丄怱寣娗昦丄摿偵擼峓嵡偵偍偗傞LOX-1儕僈儞僪傗LOX Index崅抣偺堄媊傪徹柧偡傞偙偲偑偱偒偨丅

帯椕巜昗偲偟偰偺壜擻惈

堦曽丄僐儗僗僥儘乕儖掅壓椕朄偲偺娭學傪尒傞偨傔丄僗僞僠儞搳梌偺寣拞LOX-1儕僈儞僪傊偺塭嬁傪崅帀寣徢姵幰偱夝愅偟偨丅栻暔帯椕楌偺側偄25柤偺崅帀寣徢姵幰傊僺僞僶僗僞僠儞傪6僇寧搳梌偟丄搳梌慜屻偱偺LOX-1儕僈儞僪寣拞擹搙偺曄壔傪應掕偟偨丅偦偺寢壥丄僺僞僶僗僞僠儞搳梌偵傛傝寣拞LDL僐儗僗僥儘乕儖擹搙偑掅壓偡傞偲偲傕偵丄LOX-1儕僈儞僪寣拞擹搙偺桳堄側掅壓偑娤嶡偝傟偨乮Matsumoto, T. et al. Lipids 2010乯丅LDL僐儗僗僥儘乕儖擹搙掅壓検偲LOX-1儕僈儞僪擹搙掅壓検偵偼桳堄側憡娭偼側偔丄椉幰偼偼摨帪偵婲偒偰偄傞傕偺偺丄LDL僐儗僗僥儘乕儖偑尭彮偟偨寢壥偲偟偰LOX-1儕僈儞僪偑扨偵尭彮偟偰偄傞偺偱偼側偔丄LDL掅壓嶌梡偲偼暿偺婡彉偵傛傝僗僞僠儞偑LOX-1儕僈儞僪検傪尭彮偝偣偰偄傞壜擻惈偑峫偊傜傟偨丅帯椕偵傛傞LOX-1儕僈儞僪掅壓偺梊屻傊偺塭嬁偼崱偺偲偙傠晄柧偩偑丄帯椕岠壥偺巜昗偲偟偰偺桳梡惈偑婜懸偝傟傞丅傑偨丄幘姵敪徢帪偺恌抐偺偨傔偺巜昗偲偟偰LOX-1儕僈儞僪傗sLOX-1偑巊偊傞壜擻惈傕捛媮偟偰偄偒偨偄丅

崱屻丄巹払偺應掕朄偑寬峃恌抐側偳偵棙梡偝傟傞偙偲偱丄寬忢帪偐傜摦柆峝壔惈幘姵敪徢儕僗僋傪昡壙偱偒傞傛偆偵側傝丄摦柆峝壔惈幘姵偺梊杊偵峷專偱偒傟偽偲峫偊偰偄傞丅

嶲峫暥專 

Holvoet, P. et al. Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome. JAMA, 299:2287-2293, 2008.

Itabe, H. et al. Measurement of Plasma Oxidized Low-Density Lipoprotein and its Clinical Implications. J Atheroscl Thromb, 14:1-11, 2007.

Kakutani, M., Ueda, M., Naruko, T., Masaki, T. and Sawamura, T.: Accumulation of LOX-1 ligand in plasma and atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits: Identification by a novel enzyme immunoassay. Biochem Biophys Res Commun, 282:180-185, 2001.

Iwamoto, S., Fujita, Y., Kakino, A., Yanagida, K., Matsuda, H., Yoshimoto, R. and Sawamura, T.: An Alternative Protein Standard to Measure Activity of LOX-1 Ligand Containing apoB (LAB) - Utilization of Anti-LOX-1 Single- Chain Antibody Fused to apoB Fragment. J Atheroscler Thromb, 18:818-28, 2011.

Oka, K., Yasuhara, M., Suzumura, K., Tanaka, K. and Sawamura, T.: Antioxidants suppress plasma levels of lectin-like oxidized low-density lipoprotein receptor-ligands and reduce atherosclerosis in watanabe heritable hyperlipidemic rabbits. J Cardiovasc Pharmacol, 48:177-183, 2006.

Sato, Y., Nishimichi, N., Nakano, A., Takikawa, K., Inoue, N., Matsuda, H. and Sawamura, T.: Determination of LOX-1-ligand activity in mouse plasma with a chicken monoclonal antibody for ApoB. Atherosclerosis, 200:303-309, 2008.

Ishigaki, Y., Katagiri, H., Gao, J., Yamada, T., Imai, J., Uno, K., Hasegawa, Y., Kaneko, K., Ogihara, T., Ishihara, H., Sato, Y., Takikawa, K., Nishimichi, N., Matsuda, H., Sawamura, T. and Oka, Y.: Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis. Circulation, 118:75-83, 2008.

Inoue, N., Okamura, T., Kokubo, Y., Fujita, Y., Sato, Y., Nakanishi, M., Yanagida, K., Kakino, A., Iwamoto, S., Watanabe, M., Ogura, S., Otsui, K., Matsuda, H., Uchida, K., Yoshimoto, R. and Sawamura, T.: LOX Index, a novel predictive biochemical marker for coronary heart disease and stroke. Clin Chem, 56:550-8, 2010.

Matsumoto, T., Fujita, M., Sawamura, T., Kakino, A., Sato, Y., Fujita, Y., Matsuda, H., Nakanishi, M., Uchida, K., Nakae, I., Kanda, H., Yoshida, A., Miwa, K., Hayashi, H., Mitsunami, K. and Horie, M.: Pitavastatin reduces lectin-like oxidized low-density lipoprotein receptor-1 ligands in hypercholesterolemic humans. Lipids, 45, 329-35, 2011.

尋媶奣梫
巁壔LDL庴梕懱LOX-1偺敪尒
LOX-1偲嵶朎偲偺憡屳嶌梡偐傜嵶朎愙拝丒墛徢傊
LOX-1偲CRP
LOX-1偵寢崌偡傞撪場惈偺儕億抈敀幙
LOX-1僽儘僢僇乕偺奐敪