LOX-1偲巁壔LDL偺寢崌傪慾奞偡傞暘巕傪丄怘昳桼棃偺拪弌暔乮栰嵷丄壥暔丄崚暔丄摛椶丄庽旂丄拑梩丄僴乕僽丄峺曣側偳乯偍傛偦400庬椶偐傜側傞儔僀僽儔儕乕偐傜扵嶕偟偨丅

傑偢丄僒儞僪僀僢僠ELISA朄傪梡偄偰丄LOX-1偲巁壔LDL偺寢崌傪70%埲忋慾奞偡傞怘嵽傪慖暿偟丄偙傟傜偺拞偐傜偝傜偵LOX-1敪尰嵶朎傊偺巁壔LDL偺庢傝崬傒傪70亾埲忋梷惂偡傞傕偺傪慖暿偟偨丅偙傟傜偺LOX-1慾奞妶惈偑嫮偄怘昳慺嵽偺懡偔偼丄僽僪僂庬巕丄僺乕僫僢僣庬旂丄儕儞僑億儕僼僃僲乕儖丄儅僣庽旂側偳丄崅僾儘僔傾僯僕儞娷桳怘昳偲偟偰抦傜傟傞傕偺偱偁偭偨丅偦偙偱丄慻惉偺70%埲忋偑僾儘僔傾僯僕儞椶偱峔惉偝傟傞儕儞僑億儕僼僃僲乕儖暘夋傪梡偄丄LOX-1慾奞惉暘偺摨掕傪峴偭偨丅儕儞僑億儕僼僃僲乕儖暘夋偼丄LOX-1敪尰嵶朎傊偺巁壔LDL乮10 兪g/mL乯偺寢崌傪梡検埶懚揑偵梷惂偟偨乮IC₅₀丗102 ng/mL乯丅儕儞僑億儕僼僃僲乕儖暘夋傪丄僾儘僔傾僯僕儞乛僇僥僉儞偺崿崌暘夋丄僼僃僲乕儖僇儖儃儞巁暘夋丄偦偺懠偺暘夋偵暘棧偟巁壔LDL寢崌慾奞妶惈傪應掕偟偨偲偙傠丄僾儘僔傾僯僕儞乛僇僥僉儞崿崌暘夋偺傒偑丄LOX-1敪尰嵶朎傊偺巁壔LDL偺寢崌傪慾奞偟偨丅

僾儘僔傾僯僕儞椶偍傛傃乮僄僺乯僇僥僉儞偼丄億儕僼僃僲乕儖偺堦庬偱偁傞僼儔儃僲僀僪椶偵懏偡傞壔崌暔偱偁傞丅億儕僼僃僲乕儖偼暋悢偺僼僃僲乕儖惈悈巁婎傪帩偮暘巕偱丄5000庬椶埲忋偺崪奿峔憿偑妋擣偝傟偰偍傝丄攝摐懱傕懡偄丅偟偨偑偭偰丄億儕僼僃僲乕儖偲堦岥偵尵偭偰傕幚懱偼偐側傝懡條側暔幙偺憤徧偱偁傞丅偦偺偆偪僼儔儃僲僀僪椶偼丄2偮偺儀儞僛儞娐乮A娐丄B娐乯偑3屄偺扽慺尨巕偱宷偑偭偨乮C娐乯僕僼僃僯儖僾儘僷儞峔憿傪帩偮壔崌暔偱丄攝摐懱傪娷傓偲7000庬埲忋偺峔憿偑抦傜傟偰偄傞丅僼儔儃僲僀僪偺C娐3埵偵悈巁婎偑寢崌偟偨傕偺偑僼儔僶僲乕儖椶偱丄僼儔僶僲乕儖偺A娐偍傛傃B娐偵偝傜偵悈巁婎偑晅壛偝傟偨傕偺偑僇僥僉儞椶偱偁傞丅僾儘僔傾僯僕儞椶偼乮僄僺乯僇僥僉儞偑4-6埵傕偟偔偼4-8埵偱孞傝曉偟弅崌偟偨僆儕僑儅乕偱丄2乣15検懱傪宍惉偡傞丅

僾儘僔傾僯僕儞椶偺廳崌搙偲LOX-1慾奞妶惈偺娭學傪挷傋傞偨傔丄僇僥僉儞娷桳僾儘僔傾僯僕儞暘夋偐傜丄乮僄僺乯僇僥僉儞偲丄2乣7検懱偺僾儘僔傾僯僕儞傪偦傟偧傟挷惍偟偨丅3検懱埲忋偺僾儘僔傾僯僕儞椶偼丄梡検埶懚揑偵LOX-1敪尰嵶朎傊偺巁壔LDL(10 兪g/mL)偺寢崌傪慾奞偟偨乮IC₅₀丗61 ng/mL乵3検懱乶乣27 ng/mL乵7検懱乶乯丅2検懱僾儘僔傾僯僕儞偺慾奞妶惈偼3検懱埲忋偲斾妑偟偰庛偐偭偨偑(IC₅₀丗330 ng/mL)丄偦傟偱傕1 兪g/mL偺搳梌偱LOX-1偲巁壔LDL偺寢崌傪姰慡偵梷惂偟偨丅堦曽丄乮僄僺乯僇僥僉儞偵偼LOX-1慾奞妶惈偑慡偔擣傔傜傟側偐偭偨丅

僇僥僉儞椶偺C娐2埵偲3埵偼晄惸扽慺偱偁傞偨傔丄偦偺廳崌懱偱偁傞僾儘僔傾僯僕儞椶偵偼懡條側岝妛堎惈懱偑懚嵼偡傞丅儕儞僑偵偼6庬椶偺3検懱僾儘僔傾僯僕儞偑娷傑傟傞偑丄偦偺撪丄戙昞揑側堎惈懱4庬偵偮偄偰LOX-1慾奞妶惈傪専摙偟偨丅偄偢傟偺堎惈懱傕丄LOX-1敪尰嵶朎傊偺巁壔LDL(10 兪g/mL)偺寢崌傪摨掱搙偵慾奞偟偨(IC₅₀丗41乣73 ng/mL)丅寣拞偺巁壔LDL擹搙偵傛傝嬤偄3丄偁傞偄偼1 兪g/mL偱偼3検懱僾儘僔傾僯僕儞偺IC₅₀偼26偍傛傃7 ng/mL偱偁偭偨丅偙偺偙偲偐傜丄偐側傝偺掅擹搙偱僾儘僔傾僯僕儞偑巁壔LDL寢崌慾奞岠壥傪帵偡偙偲偑柧傜偐偲側偭偨丅

僾儘僔傾僯僕儞椶偺廳崌搙偼偦傟傜傪娷傓怘嵽偵傛偭偰堎側傞偑丄僾儘僔傾僯僕儞椶偺LOX-1慾奞妶惈偑3検懱埲忋偺廳崌搙傗岝妛堎惈懱娫偱戝偒偔曄壔偟側偐偭偨偙偲偐傜丄崅僾儘僔傾僯僕儞娷桳怘昳偼偄偢傟傕LOX-1慾奞岠壥傪帵偟摼傞偲峫偊傜傟丄怘昳慺嵽偺僗僋儕乕僯儞僌寢壥偲傕崌抳偡傞丅偙傟傜偺寢壥偐傜丄儕儞僑億儕僼僃僲乕儖暘夋偑帵偟偨LOX-1慾奞妶惈偺惉暘偼僾儘僔傾僯僕儞椶偱偁傞偲寢榑偟偨丅LOX-1偲巁壔LDL偺寢崌傪掅擹搙偱慾奞偡傞壔崌暔偺曬崘偼偙偺僾儘僔傾僯僕儞偑弶傔偰偱偁傞丅

In vivo偵偍偗傞LOX-1僽儘僢僇乕偺岠壥

SHRSP儔僢僩摦柆暻傊偺帀幙捑拝儌僨儖

In vivo偵偍偗傞LOX-1僽儘僢僇乕偺岠壥傪昡壙偡傞偵偼丄摦柆峝壔徢偲椶帡偟丄抁婜娫偱昦懺嶌惉偲栻岠昡壙偑偱偒丄偐偮LOX-1偺慾奞岠壥傪娤嶡偡傞偺偵揔偟偨摦暔儌僨儖偑昁梫偱偁傞丅偦偙偱丄崅寣埑儔僢僩(SHRSP)傪梡偄偨摦柆暻傊偺帀幙捑拝儌僨儖偵偮偄偰丄偦偺桳梡惈傪傑偢専摙偟偨丅偙偺儌僨儖偼SHRSP儔僢僩傪庽棫偟偨壠怷岾抝嫗搒戝妛柤梍嫵庼偵傛傞曬崘丄偡側傢偪崅帀朾怘偍傛傃怘墫晧壸偵傛傝丄SHRSP偺挵娫枌偍傛傃擼掙摦柆偵儕儞僌忬帀幙捑拝偑媫懍偵婲偙傞偲偄偆娤嶡偵婎偯偔傕偺偱偁傞(Yamori, Y. et al. Stroke 1976)丅偙偺儌僨儖偱尒傜傟傞帀幙捑拝偼摦柆峝壔偦偺傕偺偲偼昦懺偑庒姳堎側傞傕偺偺丄弶婜偺傾僥儘乕儉偱擣傔傜傟傞帀朾慄忦偲帡偰偍傝丄憗婜摦柆峝壔偺昦曄宍惉傪夝愅偡傞忋偱桳梡側儌僨儖偱偁傞丅

偙偺崅寣埑儔僢僩挵娫枌摦柆暻帀幙捑拝偵LOX-1偑娭梌偟偰偄傞壜擻惈傪峫偊丄傑偢LOX-1偺敪尰傪SHRSP偲惓忢寣埑儔僢僩WKY偲偱斾妑偟偰傒傞偲丄SHRSP偱偼挵娫枌摦柆偺LOX-1偺mRNA偍傛傃抈敀幙偺敪尰偑挊偟偔槾恑偟偰偄傞偙偲偑傢偐偭偨丅師偵SHRSP偍傛傃WKY偵崅帀朾怘丒怘墫悈偺晧壸1丄2丄5廡娫屻偺挵娫枌摦柆傪娤嶡偡傞偲丄SHRSP偵偺傒晧壸婜娫偺挿偝偵墳偠偨帀幙捑拝偑擣傔傜傟偨丅

崅帀朾怘丒怘墫悈傪晧壸偟偨SHRSP偱偼丄挵娫枌摦柆偺撪旂嵶朎偍傛傃暯妸嬝憌偺堦晹偵LOX-1偑嫮偔敪尰偟偰偍傝丄偦偺嬊嵼偼巁壔LDL偲傛偔堦抳偟偰偄偨丅寣娗暻撪偵儅僋儘僼傽乕僕偑娤嶡偝傟側偄偙偲偐傜丄偙偺摦暔儌僨儖偱偼丄暯妸嬝偱偺帀幙偺庢傝崬傒偑槾恑偟偰偄傞偲峫偊傜傟傞丅

偦偙偱丄偙偺儌僨儖偱丄崅帀朾怘丒怘墫悈晧壸捈慜傛傝LOX-1偲巁壔LDL偲偺寢崌傪慾奞偡傞峈LOX-1峈懱傪SHRSP偵孞傝曉偟搳梌偟偰傒傞偲丄晧壸1廡娫屻偺娤嶡偱丄寣娗暻傊偺帀幙捑拝偺挊柧側梷惂傪擣傔偨丅SHRSP偵巁壔LDL傪旜惷柆傛傝搳梌偡傞偲丄挵娫枌摦柆傊偺暘晍偑1帪娫屻偵偼擣傔傜傟傞偑丄偙傟偼峈LOX-1峈懱偺慜搳梌偱梷惂偝傟偨丅傑偨丄揈弌挵娫枌摦柆傪梡偄偨燇棳幚尡偱傕摨條偺寢壥偑摼傜傟偨丅偙偺偙偲偐傜丄LOX-1傪夘偟偨巁壔LDL庢崬傒擻偑SHRSP偱娤嶡偝傟傞挵娫枌摦柆傊偺帀幙捑拝偵娭梌偟偰偄傞壜擻惈偑嫮偔帵嵈偝傟偨丅

僾儘僔傾僯僕儞偵傛傞帀幙捑拝偺梷惂

師偵丄LOX-1僽儘僢僇乕偲偟偰尒弌偟偨僾儘僔傾僯僕儞椶偺SHRSP摦柆暻帀幙捑拝儌僨儖偱偺岠壥傪専摙偟偨丅2検懱埲忋偺僾儘僔傾僯僕儞椶崿崌暔傪惗棟怘墫悈偵梟夝偟(0.5%)丄2廡娫堸椏悈偺戙傢傝偵SHRSP偵梌偊偨丅偦偺寢壥丄摦柆暻帀幙捑拝偼丄僾儘僔傾僯僕儞張抲孮偱桳堄偵梷惂偝傟偰偄偨丅

側偍丄帋尡婜娫拞丄僾儘僔傾僯僕儞張抲孮偲懳徠孮偺娫偵偼丄愛塧検丄懱廳丄寣埑丄怱攺悢丄憤僐儗僗僥儘乕儖丄HDL僐儗僗僥儘乕儖丄拞惈帀朾丄偍傛傃夁巁壔帀幙偺巜昗偱偁傞TBARS偵嵎偼擣傔傜傟側偐偭偨丅

帋尡廔椆帪偵偍偗傞3検懱偺僾儘僔傾僯僕儞C1丄偍傛傃2検懱偺僾儘僔傾僯僕儞B2偺寣拞擹搙偼丄偦傟偧傟4.9亇1.9偍傛傃7.9亇1.8 ng/mL偱偁偭偨丅僾儘僔傾僯僕儞C1偺検偼儕儞僑億儕僼僃僲乕儖撪偺慡僾儘僔傾僯僕儞椶偺6%掱搙偱偁傞偙偲傪峫椂偡傞偲丄寣拞偵偼巁壔LDL偲LOX-1偺寢崌傪慾奞偱偒傞僾儘僔傾僯僕儞椶偑偝傜偵懚嵼偡傞偲悇掕偝傟傞丅傑偨丄SHRSP偺寣拞巁壔LDL擹搙偼栺200 ng/mL掱搙偱偁傞偨傔丄僾儘僔傾僯僕儞C1偑扨撈偱LOX-1偲巁壔LDL偺寢崌傪廫暘偵慾奞偟偰偄傞偙偲傕峫偊傜傟傞丅

僾儘僔傾僯僕儞椶偼崀埑嶌梡丄帀幙掅壓嶌梡丄峈巁壔嶌梡傪帵偡偙偲偑偙傟傑偱曬崘偝傟偰偄傞丅偟偐偟杮帋尡偱偼丄僾儘僔傾僯僕儞椶偼寣埑丄寣拞帀幙検丄TBARS偵塭嬁傪梌偊側偐偭偨偙偲偐傜丄忋婰偺嶌梡傪夘偟偰寣娗暻傊偺帀幙捑拝傪梷惂偟偨壜擻惈偼掅偄偲峫偊偰偄傞偑丄杮摦暔儌僨儖偱尒傜傟偨僾儘僔傾僯僕儞椶偺岠壥偑寣娗暻忋偺LOX-1偲巁壔LDL偺寢崌慾奞偵傛傞傕偺側偺偐丄偁傞偄偼懠偺嶌梡婡彉偵傛傞傕偺偐偵偮偄偰偼崱屻偝傜偵専摙偟偰偄偒偨偄丅

僾儘僔傾僯僕儞偲僼儗儞僠僷儔僪僢僋僗

僼儔儞僗偱偼僐儗僗僥儘乕儖傗朞榓帀朾巁傪懡偔愛庢偟偰偄傞偵傕偐偐傢傜偢丄憡懳揑偵姤摦柆幘姵偵傛傞巰朣棪偑掅偄偙偲偑抦傜傟丄僼儗儞僠僷儔僪僢僋僗偲偟偰抦傜傟偰偄傞丅偦偺棟桼偑愒儚僀儞偺愛庢偵偁傞偺偱偼側偄偐偲偄偆壖愢偑偁傝丄桳岠惉暘偵偮偄偰偼丄儗僗儀儔僩儘乕儖傗僾儘僔傾僯僕儞偑偦偺岓曗偲偟偰曬崘偝傟偰偄傞丅儗僗儀儔僩儘乕儖偼僗僠儖儀僲僀僪椶偵懏偡傞壔崌暔偱丄LDL偺巁壔丄寣彫斅偺嬅廤丄暯妸嬝傗撪旂嵶朎偺憹怋丄摦柆峝壔憙偺宍惉側偳傪梷惂偡傞偙偲偑曬崘偝傟偰偄傞丅傑偨儗僗儀儔僩儘乕儖偼丄SIRT1傗IGF1丄AMPK側偳偺宱楬傪挷愡偡傞偙偲偱僇儘儕乕惂尷偺岠壥傪柾曧偡傞偑丄捈愙偺昗揑暘巕偼晄柧偱偁傞丅

堦曽丄僾儘僔傾僯僕儞傕愒儚僀儞傗僐僐傾側偳丄怱寣娗曐岇嶌梡偑偁傞偲尵傢傟傞怘昳偵懡偔娷傑傟傞丅Corder傜偼丄僄儞僪僙儕儞-1偺寣娗撪旂嵶朎偐傜偺暘斿傪愒儚僀儞偺惉暘偑梷惂偟丄偦偺暔幙傪摨掕偟偨偲偙傠僾儘僔傾僯僕儞偱偁偭偨偙偲丄僾儘僔傾僯僕儞娷検偺懡偄愒儚僀儞嶻抧偱偼丄堸庰検偑彈惈傛傝懡偄抝惈偺庻柦偑懠偺抧堟偵斾傋挿偔丄嫊寣惈怱幘姵偑彮側偄偙偲偐傜丄僾儘僔傾僯僕儞偑僼儗儞僠僷儔僪僢僋僗傪傕偨傜偡暔幙偱偁傞偲偄偆愢傪採彞偟偰偄傞(Corder, R. et al. Nature 2001, Corder, R. et al. Nature 2006)丅僼儗儞僠僷儔僪僢僋僗偺婡彉偑丄僾儘僔傾僯僕儞偵傛傞LOX-1偲巁壔LDL偺寢崌慾奞偵傛偭偰愢柧偱偒傞偲偡傟偽旕忢偵嫽枴怺偄丅

嶲峫暥專

Yamori Y., et al: Hypertension as an important factor for cerebrovascular atherogenesis in rats. Stroke 7:120-125, 1976.

Nakano, A., Inoue, N., Sato, Y., Nishimichi, N., Takikawa, K., Fujita, Y., Kakino, A., Otsui, K., Yamaguchi, S., Matsuda, H. and Sawamura, T.: LOX-1 mediates vascular lipid retention under hypertensive state. J Hypertens, 28:1273-1280, 2010.

Nishizuka, T., Fujita, Y., Sato, Y., Nakano, A., Kakino, A., Ohshima, S., Kanda, T., Yoshimoto, R. and Sawamura, T.: Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox. Proc Jpn Acad Ser B Phys Biol Sci, 87:104-113, 2011.

Corder, R., et al. Endothelin-1 synthesis reduced by red wine. Nature 414, 863-864, 2001.

Corder R., et al. Red wine procyanidins and vascular health. Nature 444:566-566, 2006.

尋媶奣梫
巁壔LDL庴梕懱LOX-1偺敪尒
LOX-1偲嵶朎偲偺憡屳嶌梡偐傜嵶朎愙拝丒墛徢傊
LOX-1偲CRP
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