Cardiology researcher Akihiro Yamauchi, who is from Japan Bio Products Co., Ltd., and who is also a joint researcher with the Department of Cardiovascular Research at the Shinshu University Graduate School of Medicine, wins Young Investigator Award
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Researchers together with society director Dr. Masataka Sata (center right)
The 45th conference of the Japanese Society for Circulation Research was held on February 5 and 6, 2016 at Tokushima. Akihiro Yamauchi, who is from Japan Bio Products Co., Ltd., and who is also a joint researcher with the Department of Cardiovascular Research at the Shinshu University Graduate School of Medicine, was presented with the Young Investigator Award for his contribution to circulation research.
The winning presentation described the role of adrenomedullin receptors in differentiating between vascular tracts and lymph ducts and regulating the homeostasis of blood vessels through the multiple receptor systems AM1 and AM2.
Yamauchi’s research used a combination of genetically modified mice and live imaging to investigate the manifestation of AM receptors AM1R and AM2R and their complementary pathophysiological functions.
The research showed how AM1R and AM2R work together to maintain homeostasis in the organism, with AM2R appearing in the early stages of inflammation to control both inflammation and drainage from lymph ducts, followed by AM1R which promotes anti-inflammatory action and tissue repair and remodeling.
The research also demonstrated that the AM2R knockout mouse can be used as a lymphatic abnormality model and also for evaluating corneal lymph duct regeneration.
It is expected that further research on AM receptors will yield new insights into potential treatments for lifestyle diseases and cancers triggered by abnormalities in the vascular system.
Details of Department of Cardiovascular Research, Institute of Pathogenesis and Disease Prevention (Website)
http://www7a.biglobe.ne.jp/~shindo/
