Discovery of a novel biomarker for diffuse alveolar damage pattern of interstitial pneumonia - A new step toward the diagnosis of interstitial pneumonia
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Image of the severe pneumonia of COVID-19: Prof Masayuki Hanaoka et al. discovered the biomarker 'stratifin', which is significantly elevated in the blood of patients with severe interstitial pneumonia.
A research group led by Professor Masayuki Hanaoka of the First Department of Internal Medicine, Shinshu University School of Medicine, and Associate Professor Atsuhito Ushiki of the Department of Medical Informatics, Shinshu University Hospital, discovered that the protein 'stratifin' is a new promising biomarker for the diagnosis of diffuse alveolar damage, the most severe pattern of interstitial pneumonia.
The research was carried out in collaboration with the National Institute of Health Sciences, Kihara Memorial Yokohama Foundation, Nippon Medical School, Chiba University, Hiroshima University, International University of Health and Welfare, Astellas Pharma Inc. and Daiichi Sankyo RD Novare Co., Ltd.
Points of Research
- The research revealed for the first time that the protein 'stratifin' is significantly elevated in the blood in patients with the most severe pattern of interstitial pneumonia.
- This pattern of interstitial pneumonia is also shown in severe cases of COVID-19.
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It is expected to measure the concentration of the ‘stratifin’ biomarker in blood to substitute the invasive surgical lung biopsy in the diagnosis of diffuse alveolar damage. The blood test is much less burdensome than the surgical lung biopsy.
The findings of this research were published in Nature Communications on October 4, 2022.
More about the paper:
Title: Stratifin as a novel diagnostic biomarker in serum for diffuse alveolar damage
Authors: Noriaki Arakawa, Atsuhito Ushiki, Mitsuhiro Abe, Shinichiro Matsuyama, Yoshinobu Saito, Takeru Kashiwada, Yasushi Horimasu, Akihiko Gemma, Koichiro Tatsumi, Noboru Hattori, Kenji Tsushima, Keiko Miyashita, Kosuke Saito, Ryosuke Nakamura, Takeshi Toyoda, Kumiko Ogawa, Motonobu Sato, Kazuhiko Takamatsu, Kazuhiko Mori, Takayoshi Nishiya, Takashi Izumi, Yasuo Ohno, Yoshiro Saito, Masayuki Hanaoka
Journal：Nature Communications. 2022 Oct 4;13(1):5854.
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